Reconsideration of Antinucleocapsid IgG Antibody as a Marker of SARS-CoV-2 Infection Postvaccination for Mild COVID-19 Patients

Santosh Dhakal; Tong Yu; Anna Yin; Nora Pisanic; Zoe O. Demko; Annukka A.R. Antar; Andrea L. Cox; Christopher D. Heaney; Yukari C. Manabe; Sabra L. Klein

doi:10.1093/ofid/ofac677

Reconsideration of Antinucleocapsid IgG Antibody as a Marker of SARS-CoV-2 Infection Postvaccination for Mild COVID-19 Patients

Santosh Dhakal
, Tong Yu
, Anna Yin
, Nora Pisanic
, Zoe O. Demko
, Annukka A.R. Antar
, Andrea L. Cox
, Christopher D. Heaney
, Yukari C. Manabe
, Sabra L. Klein

Research output: Contribution to journal › Article › peer-review

Abstract

Antinucleocapsid (anti-N) immunoglobulin G antibody responses were lower in plasma and oral fluid after severe acute respiratory syndrome coronavirus 2 infection in vaccinated patients compared with patients infected before vaccination or infected without vaccination. This raises questions about the long-term use of anti-N antibodies as a marker for natural infection for surveillance.

Original language	English (US)
Article number	ofac677
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofac677
State	Published - Jan 1 2023

Keywords

COVID-19
hybrid immunity
nucleocapsid antibody
surveillance
vaccines

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofac677

Cite this

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title = "Reconsideration of Antinucleocapsid IgG Antibody as a Marker of SARS-CoV-2 Infection Postvaccination for Mild COVID-19 Patients",

abstract = "Antinucleocapsid (anti-N) immunoglobulin G antibody responses were lower in plasma and oral fluid after severe acute respiratory syndrome coronavirus 2 infection in vaccinated patients compared with patients infected before vaccination or infected without vaccination. This raises questions about the long-term use of anti-N antibodies as a marker for natural infection for surveillance.",

keywords = "COVID-19, hybrid immunity, nucleocapsid antibody, surveillance, vaccines",

author = "Santosh Dhakal and Tong Yu and Anna Yin and Nora Pisanic and Demko, \{Zoe O.\} and Antar, \{Annukka A.R.\} and Cox, \{Andrea L.\} and Heaney, \{Christopher D.\} and Manabe, \{Yukari C.\} and Klein, \{Sabra L.\}",

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doi = "10.1093/ofid/ofac677",

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AU - Dhakal, Santosh

AU - Yu, Tong

AU - Yin, Anna

AU - Pisanic, Nora

AU - Demko, Zoe O.

AU - Antar, Annukka A.R.

AU - Cox, Andrea L.

AU - Heaney, Christopher D.

AU - Manabe, Yukari C.

AU - Klein, Sabra L.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Antinucleocapsid (anti-N) immunoglobulin G antibody responses were lower in plasma and oral fluid after severe acute respiratory syndrome coronavirus 2 infection in vaccinated patients compared with patients infected before vaccination or infected without vaccination. This raises questions about the long-term use of anti-N antibodies as a marker for natural infection for surveillance.

AB - Antinucleocapsid (anti-N) immunoglobulin G antibody responses were lower in plasma and oral fluid after severe acute respiratory syndrome coronavirus 2 infection in vaccinated patients compared with patients infected before vaccination or infected without vaccination. This raises questions about the long-term use of anti-N antibodies as a marker for natural infection for surveillance.

KW - COVID-19

KW - hybrid immunity

KW - nucleocapsid antibody

KW - surveillance

KW - vaccines

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ER -

Reconsideration of Antinucleocapsid IgG Antibody as a Marker of SARS-CoV-2 Infection Postvaccination for Mild COVID-19 Patients

Abstract

Keywords

ASJC Scopus subject areas

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