TY - JOUR
T1 - Recommendations for standardized definitions, clinical assessment, and future research in pediatric clinically unsuspected venous thromboembolism
T2 - Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis
AU - Betensky, Marisol
AU - Kulkarni, Ketan
AU - Rizzi, Mattia
AU - Jones, Sophie
AU - Brandão, Leonardo R.
AU - Faustino, Edward Vincent S.
AU - Goldenberg, Neil A.
AU - Sharathkumar, Anjali
N1 - Publisher Copyright:
© 2022 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.
PY - 2022/7
Y1 - 2022/7
N2 - Clinically unsuspected venous thromboembolism (VTE) in children is defined as a VTE diagnosed via imaging test performed for surveillance (i.e., with an intent to identify clinically silent VTEs) or incidentally found (most often via imaging performed for evaluation of regional pathology unrelated to VTE) in the absence of any VTE-associated signs or symptoms. Our understanding of the clinical significance of these events in children is limited by a paucity of data on the epidemiology and outcomes of this complication. There is an urgent need for further research in this area to inform optimal management. Recognizing this knowledge gap, this Task Force has previously published a systematic review of the literature in this topic. We now provide guidance recommendations for standardization of definitions and identify future research needs on clinically unsuspected VTE in children. These recommendations will serve to enhance the quantity and quality of evidence on the topic and facilitate the design and execution of cooperative observational studies, and interventional trials of risk-stratified management approaches aimed at preventing and optimizing long-term outcomes of clinically unsuspected VTE in children.
AB - Clinically unsuspected venous thromboembolism (VTE) in children is defined as a VTE diagnosed via imaging test performed for surveillance (i.e., with an intent to identify clinically silent VTEs) or incidentally found (most often via imaging performed for evaluation of regional pathology unrelated to VTE) in the absence of any VTE-associated signs or symptoms. Our understanding of the clinical significance of these events in children is limited by a paucity of data on the epidemiology and outcomes of this complication. There is an urgent need for further research in this area to inform optimal management. Recognizing this knowledge gap, this Task Force has previously published a systematic review of the literature in this topic. We now provide guidance recommendations for standardization of definitions and identify future research needs on clinically unsuspected VTE in children. These recommendations will serve to enhance the quantity and quality of evidence on the topic and facilitate the design and execution of cooperative observational studies, and interventional trials of risk-stratified management approaches aimed at preventing and optimizing long-term outcomes of clinically unsuspected VTE in children.
KW - asymptomatic venous thromboembolism
KW - pediatric
KW - unsuspected venous thromboembolism
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U2 - 10.1111/jth.15731
DO - 10.1111/jth.15731
M3 - Review article
C2 - 35570328
AN - SCOPUS:85132626652
SN - 1538-7933
VL - 20
SP - 1729
EP - 1734
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
IS - 7
ER -