Abstract
Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics. Copyright (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 200-204 |
Number of pages | 5 |
Journal | Trends in biochemical sciences |
Volume | 25 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2000 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology