Receptor usage and cell entry of porcine epidemic diarrhea coronavirus

Chang Liu, Jian Tang, Yuanmei Ma, Xueya Liang, Yang Yang, Guiqing Peng, Qianqian Qi, Shibo Jiang, Jianrong Li, Lanying Du, Fang Li

Research output: Contribution to journalArticlepeer-review


Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.

Original languageEnglish (US)
Pages (from-to)6121-6125
Number of pages5
JournalJournal of virology
Issue number11
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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