Abstract
The transmembrane (TM) domains of receptor tyrosine kinases (RTKs) play an active role in signaling. They contribute to the stability of full-length receptor dimers and to maintaining a signaling-competent dimeric receptor conformation. In an exciting new development, two structures of RTK TM domains have been solved, a break-through achievement in the field. here we review these structures, and we discuss recent studies of RTK TM domain dimerization energetics, possible synergies between domains, and the effects of pathogenic RTK TM mutations on structure and dimerization.
Original language | English (US) |
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Pages (from-to) | 249-254 |
Number of pages | 6 |
Journal | Cell Adhesion and Migration |
Volume | 4 |
Issue number | 2 |
DOIs | |
State | Published - 2010 |
Keywords
- Dimer structure
- Dimerization thermodynamics
- Pathogenic mutations
- Receptor tyrosine kinases
- Transmembrane domain
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology