Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor

Elizabeth Alva; Jeffrey Rubens; Susan Chi; Tom Rosenberg; Alyssa Reddy; Eric H. Raabe; Ashley Margol

doi:10.1016/j.neo.2023.100880

Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor

Elizabeth Alva, Jeffrey Rubens, Susan Chi, Tom Rosenberg, Alyssa Reddy, Eric H. Raabe, Ashley Margol

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central nervous system embryonal tumors. We here review prior AT/RT clinical trials and highlight promising pre-clinical results that may inform novel clinical approaches to this aggressive cancer.

Original language	English (US)
Article number	100880
Journal	Neoplasia (United States)
Volume	37
DOIs	https://doi.org/10.1016/j.neo.2023.100880
State	Published - Mar 2023

Keywords

INI1
MEK
MYC
adaptive
clinical trial
epigenetics
mTOR

ASJC Scopus subject areas

Cancer Research

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10.1016/j.neo.2023.100880

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title = "Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor",

abstract = "Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central nervous system embryonal tumors. We here review prior AT/RT clinical trials and highlight promising pre-clinical results that may inform novel clinical approaches to this aggressive cancer.",

keywords = "INI1, MEK, MYC, adaptive, clinical trial, epigenetics, mTOR",

author = "Elizabeth Alva and Jeffrey Rubens and Susan Chi and Tom Rosenberg and Alyssa Reddy and Raabe, {Eric H.} and Ashley Margol",

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doi = "10.1016/j.neo.2023.100880",

language = "English (US)",

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AU - Rubens, Jeffrey

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AU - Rosenberg, Tom

AU - Reddy, Alyssa

AU - Raabe, Eric H.

AU - Margol, Ashley

PY - 2023/3

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AB - Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central nervous system embryonal tumors. We here review prior AT/RT clinical trials and highlight promising pre-clinical results that may inform novel clinical approaches to this aggressive cancer.

KW - INI1

KW - MEK

KW - MYC

KW - adaptive

KW - clinical trial

KW - epigenetics

KW - mTOR

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ER -

Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor

Abstract

Keywords

ASJC Scopus subject areas

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