Recent developments in HLA-haploidentical transplantations

Margaret Showel; Ephraim J. Fuchs

doi:10.1016/j.beha.2015.10.011

Recent developments in HLA-haploidentical transplantations

Margaret Showel, Ephraim J. Fuchs

School of Medicine

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.

Original language	English (US)
Pages (from-to)	141-146
Number of pages	6
Journal	Best Practice and Research: Clinical Haematology
Volume	28
Issue number	2-3
DOIs	https://doi.org/10.1016/j.beha.2015.10.011
State	Published - Jun 1 2015

Keywords

Acute myeloid leukemia
Cyclophosphamide
Graft versus host disease
HLA-haploidentical transplantation
Matched related donor
Matched unrelated donor
Mismatched unrelated donor
Relapse

ASJC Scopus subject areas

Oncology
Clinical Biochemistry

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10.1016/j.beha.2015.10.011

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title = "Recent developments in HLA-haploidentical transplantations",

abstract = "While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.",

keywords = "Acute myeloid leukemia, Cyclophosphamide, Graft versus host disease, HLA-haploidentical transplantation, Matched related donor, Matched unrelated donor, Mismatched unrelated donor, Relapse",

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AU - Fuchs, Ephraim J.

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AB - While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.

KW - Acute myeloid leukemia

KW - Cyclophosphamide

KW - Graft versus host disease

KW - HLA-haploidentical transplantation

KW - Matched related donor

KW - Matched unrelated donor

KW - Mismatched unrelated donor

KW - Relapse

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ER -

Recent developments in HLA-haploidentical transplantations

Abstract

Keywords

ASJC Scopus subject areas

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