Recent advances in the genetics of obsessive-compulsive disorder

Jack F. Samuels

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


This article reviews recent developments in understanding the genetic etiology of obsessive-compulsive disorder (OCD). Family studies provide further support for the familial aggregation of OCD. Genome-wide linkage studies indicate that specific chromosomal regions are linked to OCD. Moreover, results from recent molecular genetic studies suggest that several candidate genes are associated with OCD. However, specific genes causing OCD have not been conclusively identified, and the molecular pathogenesis of the disorder has not been elucidated. The search for genes is complicated by the clinical and etiologic heterogeneity of OCD, as well as the possibility of gene-gene and gene-environment interactions. Despite this complexity, further refinement of the phenotype and developments in molecular and statistical genetics hold promise for further deepening our genetic understanding of OCD in the future.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalCurrent psychiatry reports
Issue number4
StatePublished - Aug 4 2009

ASJC Scopus subject areas

  • Psychiatry and Mental health


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