Recent advances in radiosurgical management of brain metastases

Hannah Marie Devoid; Emory R. McTyre; Brandi R. Page; Linda Metheny-Barlow; Jimmy Ruiz; Michael D. Chan

doi:10.2741/S458

Recent advances in radiosurgical management of brain metastases

Hannah Marie Devoid, Emory R. McTyre, Brandi R. Page, Linda Metheny-Barlow, Jimmy Ruiz, Michael D. Chan

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Stereotactic radiosurgery (SRS) has become a widely available treatment option for patients with brain metastases. Recent clinical trials suggest that SRS can be used without upfront whole brain radiotherapy (WBRT), resulting in several clinical dilemmas in the current daily practice of SRS. The proper patient selection for SRS or WBRT continues to evolve. Statistical models to predict when new brain metastases will occur as well as who will experience neurologic death have been developed. The optimization of imaging continues for both detection of brain metastases and response assessment. Larger brain metastases continue to pose a challenge to practitioners to find options to optimize the therapeutic ratio. The current review addresses the current state of the scientific literature for these clinical dilemmas.

Original language	English (US)
Pages (from-to)	203-214
Number of pages	12
Journal	Frontiers in Bioscience - Scholar
Volume	8
Issue number	1
DOIs	https://doi.org/10.2741/S458
State	Published - Jan 1 2016
Externally published	Yes

Keywords

Brain metastasis
Review
Stereotactic radiosurgery

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.2741/S458

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AU - Page, Brandi R.

AU - Metheny-Barlow, Linda

AU - Ruiz, Jimmy

AU - Chan, Michael D.

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AB - Stereotactic radiosurgery (SRS) has become a widely available treatment option for patients with brain metastases. Recent clinical trials suggest that SRS can be used without upfront whole brain radiotherapy (WBRT), resulting in several clinical dilemmas in the current daily practice of SRS. The proper patient selection for SRS or WBRT continues to evolve. Statistical models to predict when new brain metastases will occur as well as who will experience neurologic death have been developed. The optimization of imaging continues for both detection of brain metastases and response assessment. Larger brain metastases continue to pose a challenge to practitioners to find options to optimize the therapeutic ratio. The current review addresses the current state of the scientific literature for these clinical dilemmas.

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Recent advances in radiosurgical management of brain metastases

Abstract

Keywords

ASJC Scopus subject areas

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