Recent advances in our understanding of Parkinson's disease

Seong Who Kim; Han Seok Ko; Valina L. Dawson; Ted M. Dawson

doi:10.1016/j.ddmec.2005.11.015

Recent advances in our understanding of Parkinson's disease

Seong Who Kim, Han Seok Ko, Valina L. Dawson, Ted M. Dawson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with complex causes. Through scientific investigation of the gene products identified to be linked to inherited PD, common potential mechanisms in the development of PD are being unveiled, that is, defects in mitochondrial function as well as protein folding and degradation through the ubiquitin-proteosomal system leading to cell death. Understanding these mechanisms might lead to new arenas of therapeutic intervention.

Original language	English (US)
Pages (from-to)	427-433
Number of pages	7
Journal	Drug Discovery Today: Disease Mechanisms
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.ddmec.2005.11.015
State	Published - 2005

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmec.2005.11.015

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@article{751ccfb84abb4b969e82a669d9274359,

title = "Recent advances in our understanding of Parkinson's disease",

abstract = "Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with complex causes. Through scientific investigation of the gene products identified to be linked to inherited PD, common potential mechanisms in the development of PD are being unveiled, that is, defects in mitochondrial function as well as protein folding and degradation through the ubiquitin-proteosomal system leading to cell death. Understanding these mechanisms might lead to new arenas of therapeutic intervention.",

author = "Kim, {Seong Who} and Ko, {Han Seok} and Dawson, {Valina L.} and Dawson, {Ted M.}",

note = "Funding Information: Supported by grants from the NIH, NINDS NS 38377, NS 051468, NS 047565, the Lee Martin Trust, the Sylvia Nachlas Trust, the National Parkinson Foundation and the American Parkinson's Disease Association. S.W.K. is the Herbert Freidberg Fellow in Parkinson's Disease Research. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases.",

year = "2005",

doi = "10.1016/j.ddmec.2005.11.015",

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journal = "Drug Discovery Today: Disease Mechanisms",

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T1 - Recent advances in our understanding of Parkinson's disease

AU - Kim, Seong Who

AU - Ko, Han Seok

AU - Dawson, Valina L.

AU - Dawson, Ted M.

N1 - Funding Information: Supported by grants from the NIH, NINDS NS 38377, NS 051468, NS 047565, the Lee Martin Trust, the Sylvia Nachlas Trust, the National Parkinson Foundation and the American Parkinson's Disease Association. S.W.K. is the Herbert Freidberg Fellow in Parkinson's Disease Research. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases.

PY - 2005

Y1 - 2005

N2 - Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with complex causes. Through scientific investigation of the gene products identified to be linked to inherited PD, common potential mechanisms in the development of PD are being unveiled, that is, defects in mitochondrial function as well as protein folding and degradation through the ubiquitin-proteosomal system leading to cell death. Understanding these mechanisms might lead to new arenas of therapeutic intervention.

AB - Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with complex causes. Through scientific investigation of the gene products identified to be linked to inherited PD, common potential mechanisms in the development of PD are being unveiled, that is, defects in mitochondrial function as well as protein folding and degradation through the ubiquitin-proteosomal system leading to cell death. Understanding these mechanisms might lead to new arenas of therapeutic intervention.

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DO - 10.1016/j.ddmec.2005.11.015

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AN - SCOPUS:33645063196

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JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 4

ER -

Recent advances in our understanding of Parkinson's disease

Abstract

ASJC Scopus subject areas

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