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REBOA-Induced Ischemia-Reperfusion Injury

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Resuscitative endovascular balloon occlusion of the aorta (REBOA)-induced ischemia-reperfusion injury (IRI) represents a complex pathophysiologic process involving dysfunction of intracellular and extracellular components responsible for metabolic, thrombotic, and inflammatory signaling and cellular function. Mitigation strategies following repair and re-establishment of end-organ perfusion include surgical and pharmacologic considerations and adjuncts. Currently, there is a paucity of clinical data concerning the incidence and associated clinical ramifications of IRI following REBOA deployment. Given this limitation, this chapter aims to review IRI as a result of REBOA and discuss the current literature on REBOA-associated IRI mitigation strategies.

Original languageEnglish (US)
Title of host publicationHot Topics in Acute Care Surgery and Trauma
PublisherSpringer Nature
Pages121-133
Number of pages13
DOIs
StatePublished - 2020
Externally publishedYes

Publication series

NameHot Topics in Acute Care Surgery and Trauma
VolumePart F4655
ISSN (Print)2520-8284
ISSN (Electronic)2520-8292

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

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