Real time sampling and analysis of biological biomarkers by tof mass spectrometry

Miquel D. Antoine; Wayne A. Bryden; Harvey W. Ko; Peter F. Scholl; Richard S. Potember; Robert J. Cotter

doi:10.4271/981740

Real time sampling and analysis of biological biomarkers by tof mass spectrometry

Miquel D. Antoine, Wayne A. Bryden, Harvey W. Ko, Peter F. Scholl, Richard S. Potember, Robert J. Cotter

Research output: Contribution to journal › Conference article › peer-review

Abstract

We are developing and testing a small, efficient time-of-flight mass spectrometer to rapidly identify important biomarkers for human space exploration. We are also evaluating critical biomarkers that are indicators of muscle atrophy and bone demineralization associated with space travel. We have recorded mass spectral signatures of several biomarkers. Compounds under investigation include: insulin-like growth factors (IGF-I), urinary 3-methylhistidine, estradiol, and creatinine. We have also completed initial studies of trivalent hydroxypyridinium crosslinks which are excreted as free pyridinolines in urine during bone resorption.

Original language	English (US)
Journal	SAE Technical Papers
DOIs	https://doi.org/10.4271/981740
State	Published - 1998
Externally published	Yes
Event	28th International Conference on Environmental Systems - Danvers, MA, United States Duration: Jul 13 1998 → Jul 16 1998

ASJC Scopus subject areas

Automotive Engineering
Safety, Risk, Reliability and Quality
Pollution
Industrial and Manufacturing Engineering

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title = "Real time sampling and analysis of biological biomarkers by tof mass spectrometry",

abstract = "We are developing and testing a small, efficient time-of-flight mass spectrometer to rapidly identify important biomarkers for human space exploration. We are also evaluating critical biomarkers that are indicators of muscle atrophy and bone demineralization associated with space travel. We have recorded mass spectral signatures of several biomarkers. Compounds under investigation include: insulin-like growth factors (IGF-I), urinary 3-methylhistidine, estradiol, and creatinine. We have also completed initial studies of trivalent hydroxypyridinium crosslinks which are excreted as free pyridinolines in urine during bone resorption.",

author = "Antoine, {Miquel D.} and Bryden, {Wayne A.} and Ko, {Harvey W.} and Scholl, {Peter F.} and Potember, {Richard S.} and Cotter, {Robert J.}",

year = "1998",

doi = "10.4271/981740",

language = "English (US)",

journal = "SAE Technical Papers",

issn = "0148-7191",

publisher = "SAE International",

note = "28th International Conference on Environmental Systems ; Conference date: 13-07-1998 Through 16-07-1998",

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TY - JOUR

T1 - Real time sampling and analysis of biological biomarkers by tof mass spectrometry

AU - Antoine, Miquel D.

AU - Bryden, Wayne A.

AU - Ko, Harvey W.

AU - Scholl, Peter F.

AU - Potember, Richard S.

AU - Cotter, Robert J.

PY - 1998

Y1 - 1998

N2 - We are developing and testing a small, efficient time-of-flight mass spectrometer to rapidly identify important biomarkers for human space exploration. We are also evaluating critical biomarkers that are indicators of muscle atrophy and bone demineralization associated with space travel. We have recorded mass spectral signatures of several biomarkers. Compounds under investigation include: insulin-like growth factors (IGF-I), urinary 3-methylhistidine, estradiol, and creatinine. We have also completed initial studies of trivalent hydroxypyridinium crosslinks which are excreted as free pyridinolines in urine during bone resorption.

AB - We are developing and testing a small, efficient time-of-flight mass spectrometer to rapidly identify important biomarkers for human space exploration. We are also evaluating critical biomarkers that are indicators of muscle atrophy and bone demineralization associated with space travel. We have recorded mass spectral signatures of several biomarkers. Compounds under investigation include: insulin-like growth factors (IGF-I), urinary 3-methylhistidine, estradiol, and creatinine. We have also completed initial studies of trivalent hydroxypyridinium crosslinks which are excreted as free pyridinolines in urine during bone resorption.

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DO - 10.4271/981740

M3 - Conference article

AN - SCOPUS:85072471184

SN - 0148-7191

JO - SAE Technical Papers

JF - SAE Technical Papers

T2 - 28th International Conference on Environmental Systems

Y2 - 13 July 1998 through 16 July 1998

ER -

Real time sampling and analysis of biological biomarkers by tof mass spectrometry

Abstract

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