Real time sampling and analysis of biological biomarkers by tof mass spectrometry

Miquel D. Antoine, Wayne A. Bryden, Harvey W. Ko, Peter F. Scholl, Richard S. Potember, Robert J. Cotter

Research output: Contribution to journalConference articlepeer-review


We are developing and testing a small, efficient time-of-flight mass spectrometer to rapidly identify important biomarkers for human space exploration. We are also evaluating critical biomarkers that are indicators of muscle atrophy and bone demineralization associated with space travel. We have recorded mass spectral signatures of several biomarkers. Compounds under investigation include: insulin-like growth factors (IGF-I), urinary 3-methylhistidine, estradiol, and creatinine. We have also completed initial studies of trivalent hydroxypyridinium crosslinks which are excreted as free pyridinolines in urine during bone resorption.

Original languageEnglish (US)
JournalSAE Technical Papers
StatePublished - 1998
Externally publishedYes
Event28th International Conference on Environmental Systems - Danvers, MA, United States
Duration: Jul 13 1998Jul 16 1998

ASJC Scopus subject areas

  • Automotive Engineering
  • Safety, Risk, Reliability and Quality
  • Pollution
  • Industrial and Manufacturing Engineering


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