Real-time MRI guided atrial septal puncture and balloon septostomy in swine

Amish N. Raval, Parag V. Karmarkar, Michael A. Guttman, Cengizhan Ozturk, Ranil DeSilva, Ronnier J. Aviles, Victor J. Wright, William H. Schenke, Ergin Atalar, Elliot R. McVeigh, Robert J. Lederman

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Cardiac perforation during atrial septal puncture (ASP) might be avoided by improved image guidance. X-ray fluoroscopy Q(RF), which guides ASP, visualizes tissue poorly and does not convey depth information. Ultrasound is limited by device shadows and constrained imaging windows. Alternatively, real-time MRI (rtMRI) provides excellent tissue contrast in any orientation and may enable ASP and balloon atrial septostomy (BAS) in swine. Custom MRI catheters incorporated "active" (receiver antenna) and "passive" (iron or gadolinium) elements. Wholly rtMRI-guided transfemoral ASP and BAS were performed in 10 swine in a 1.5T interventional suite. Hemodynamic results were measured with catheters and velocity encoded MRI. Successful ASP was performed in all 10 animals. Necropsy confirmed septostomy confined within the fossa ovalis in all. BAS was successful in 9/10 animals. Antenna failure in a re-used needle led to inadvertent vena cava tear prior to BAS in 1 animal. ASP in the same animal was easily performed using a new needle. rtMRI illustrated clear device-tissue-lumen relationships in multiple orientations, and facilitated simple ASP and BAS. The mean procedure time was 19 ± 10 minutes. Septostomy achieved a mean left to right shunt ratio of 1.3:1 in these healthy animals. Interactive rtMRI permits rapid transcatheter ASP and BAS in swine. Further technical development may enable novel applications.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Issue number4
StatePublished - Apr 2006
Externally publishedYes


  • Atrial septal puncture
  • Congenital heart disease
  • Interventional MRI
  • Magnetic resonance
  • Real-time magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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