Reading within the lines: Naturally processed peptides displayed by MHC class I molecules

Nilabh Shastri; Thomas Serwold; Pedro Paz

doi:10.1016/S0952-7915(98)80241-0

Reading within the lines: Naturally processed peptides displayed by MHC class I molecules

Nilabh Shastri, Thomas Serwold, Pedro Paz

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A typical mammalian cell contains tens of thousands of different gene products. Snippets of this genetic information are displayed on the cell surface by MHC class I molecules as short peptides for immune surveillance by CD8⁺ T lymphocytes. Genetic and biochemical analysis of these peptides is revealing novel sources and mechanisms by which these peptide/MHC class I complexes arise.

Original language	English (US)
Pages (from-to)	137-144
Number of pages	8
Journal	Current Opinion in Immunology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/S0952-7915(98)80241-0
State	Published - Apr 1998
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0952-7915(98)80241-0

Cite this

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title = "Reading within the lines: Naturally processed peptides displayed by MHC class I molecules",

abstract = "A typical mammalian cell contains tens of thousands of different gene products. Snippets of this genetic information are displayed on the cell surface by MHC class I molecules as short peptides for immune surveillance by CD8+ T lymphocytes. Genetic and biochemical analysis of these peptides is revealing novel sources and mechanisms by which these peptide/MHC class I complexes arise.",

author = "Nilabh Shastri and Thomas Serwold and Pedro Paz",

note = "Funding Information: We are grateful to members of our laboratory for stimulating discussions. Research in this laboratory is supported by grants from the National Institutes of Health.",

year = "1998",

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doi = "10.1016/S0952-7915(98)80241-0",

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T2 - Naturally processed peptides displayed by MHC class I molecules

AU - Shastri, Nilabh

AU - Serwold, Thomas

AU - Paz, Pedro

N1 - Funding Information: We are grateful to members of our laboratory for stimulating discussions. Research in this laboratory is supported by grants from the National Institutes of Health.

PY - 1998/4

Y1 - 1998/4

N2 - A typical mammalian cell contains tens of thousands of different gene products. Snippets of this genetic information are displayed on the cell surface by MHC class I molecules as short peptides for immune surveillance by CD8+ T lymphocytes. Genetic and biochemical analysis of these peptides is revealing novel sources and mechanisms by which these peptide/MHC class I complexes arise.

AB - A typical mammalian cell contains tens of thousands of different gene products. Snippets of this genetic information are displayed on the cell surface by MHC class I molecules as short peptides for immune surveillance by CD8+ T lymphocytes. Genetic and biochemical analysis of these peptides is revealing novel sources and mechanisms by which these peptide/MHC class I complexes arise.

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Reading within the lines: Naturally processed peptides displayed by MHC class I molecules

Abstract

ASJC Scopus subject areas

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