Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus

Smriti Mehra; Nadia A. Golden; Noton K. Dutta; Cecily C. Midkiff; X. Alvarez; Lara A. Doyle; Majdouline Asher; Kasi Russell-Lodrigue; Chris Monjure; Chad J. Roy; James L. Blanchard; Peter J. Didier; Ronald S. Veazey; Andrew A. Lackner; Deepak Kaushal

doi:10.1111/j.1600-0684.2011.00485.x

Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus

Smriti Mehra, Nadia A. Golden, Noton K. Dutta, Cecily C. Midkiff, X. Alvarez, Lara A. Doyle, Majdouline Asher, Kasi Russell-Lodrigue, Chris Monjure, Chad J. Roy, James L. Blanchard, Peter J. Didier, Ronald S. Veazey, Andrew A. Lackner, Deepak Kaushal

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Background: Tuberculosis (TB) and AIDS together present a devastating public health challenge. Over 3million deaths every year are attributed to these twin epidemics. Annually, ~11 million people are coinfected with HIV and Mycobacterium tuberculosis (Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation. Methodology Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they can also be used to model coinfection. Using clinical, pathological, and microbiological data, we addressed whether latent TB infection in rhesus macaques can be reactivated by infection with simian immunodeficiency virus (SIV). Results A low-dose aerosol infection of rhesus macaques with Mtb caused latent, asymptomatic TB infection. Infection of macaques exhibiting latent TB with a rhesus-specific strain of SIV significantly reactivated TB. Conclusions Rhesus macaques are excellent model of TB/AIDS coinfection and can be used to study the phenomena of TB latency and reactivation.

Original language	English (US)
Pages (from-to)	233-243
Number of pages	11
Journal	Journal of medical primatology
Volume	40
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0684.2011.00485.x
State	Published - Aug 2011
Externally published	Yes

Keywords

Latency
M. tuberculosis
Macaque
Non-human primate
Reactivation
TB/AIDS coinfection

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/j.1600-0684.2011.00485.x

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Mehra, S., Golden, N. A., Dutta, N. K., Midkiff, C. C., Alvarez, X., Doyle, L. A., Asher, M., Russell-Lodrigue, K., Monjure, C., Roy, C. J., Blanchard, J. L., Didier, P. J., Veazey, R. S., Lackner, A. A., & Kaushal, D. (2011). Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus. Journal of medical primatology, 40(4), 233-243. https://doi.org/10.1111/j.1600-0684.2011.00485.x

Mehra, S, Golden, NA, Dutta, NK, Midkiff, CC, Alvarez, X, Doyle, LA, Asher, M, Russell-Lodrigue, K, Monjure, C, Roy, CJ, Blanchard, JL, Didier, PJ, Veazey, RS, Lackner, AA & Kaushal, D 2011, 'Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus', Journal of medical primatology, vol. 40, no. 4, pp. 233-243. https://doi.org/10.1111/j.1600-0684.2011.00485.x

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title = "Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus",

abstract = "Background: Tuberculosis (TB) and AIDS together present a devastating public health challenge. Over 3million deaths every year are attributed to these twin epidemics. Annually, ~11 million people are coinfected with HIV and Mycobacterium tuberculosis (Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation. Methodology Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they can also be used to model coinfection. Using clinical, pathological, and microbiological data, we addressed whether latent TB infection in rhesus macaques can be reactivated by infection with simian immunodeficiency virus (SIV). Results A low-dose aerosol infection of rhesus macaques with Mtb caused latent, asymptomatic TB infection. Infection of macaques exhibiting latent TB with a rhesus-specific strain of SIV significantly reactivated TB. Conclusions Rhesus macaques are excellent model of TB/AIDS coinfection and can be used to study the phenomena of TB latency and reactivation.",

keywords = "Latency, M. tuberculosis, Macaque, Non-human primate, Reactivation, TB/AIDS coinfection",

author = "Smriti Mehra and Golden, {Nadia A.} and Dutta, {Noton K.} and Midkiff, {Cecily C.} and X. Alvarez and Doyle, {Lara A.} and Majdouline Asher and Kasi Russell-Lodrigue and Chris Monjure and Roy, {Chad J.} and Blanchard, {James L.} and Didier, {Peter J.} and Veazey, {Ronald S.} and Lackner, {Andrew A.} and Deepak Kaushal",

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AU - Alvarez, X.

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AU - Roy, Chad J.

AU - Blanchard, James L.

AU - Didier, Peter J.

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N2 - Background: Tuberculosis (TB) and AIDS together present a devastating public health challenge. Over 3million deaths every year are attributed to these twin epidemics. Annually, ~11 million people are coinfected with HIV and Mycobacterium tuberculosis (Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation. Methodology Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they can also be used to model coinfection. Using clinical, pathological, and microbiological data, we addressed whether latent TB infection in rhesus macaques can be reactivated by infection with simian immunodeficiency virus (SIV). Results A low-dose aerosol infection of rhesus macaques with Mtb caused latent, asymptomatic TB infection. Infection of macaques exhibiting latent TB with a rhesus-specific strain of SIV significantly reactivated TB. Conclusions Rhesus macaques are excellent model of TB/AIDS coinfection and can be used to study the phenomena of TB latency and reactivation.

AB - Background: Tuberculosis (TB) and AIDS together present a devastating public health challenge. Over 3million deaths every year are attributed to these twin epidemics. Annually, ~11 million people are coinfected with HIV and Mycobacterium tuberculosis (Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation. Methodology Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they can also be used to model coinfection. Using clinical, pathological, and microbiological data, we addressed whether latent TB infection in rhesus macaques can be reactivated by infection with simian immunodeficiency virus (SIV). Results A low-dose aerosol infection of rhesus macaques with Mtb caused latent, asymptomatic TB infection. Infection of macaques exhibiting latent TB with a rhesus-specific strain of SIV significantly reactivated TB. Conclusions Rhesus macaques are excellent model of TB/AIDS coinfection and can be used to study the phenomena of TB latency and reactivation.

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Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus

Abstract

Keywords

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