Rationale and design of the prone position and respiratory outcomes in non-intubated COVID-19 patients: The “PRONE” study

Eugene Friedman; John Franzone; Emily R. Ko; Kristin Corey; Jason Mock; Naseem Alavian; Adam Schwartz; M. Bradley Drummond; Tomeka Suber; Kelsey Linstrum; William Bain; Saramaria Afanador Castiblanco; Martin Zak; Sandra Zaeh; Ishaan Gupta; Mahendra Damarla; Naresh M. Punjabi

doi:10.1016/j.cct.2021.106541

Rationale and design of the prone position and respiratory outcomes in non-intubated COVID-19 patients: The “PRONE” study

Eugene Friedman, John Franzone, Emily R. Ko, Kristin Corey, Jason Mock, Naseem Alavian, Adam Schwartz, M. Bradley Drummond, Tomeka Suber, Kelsey Linstrum, William Bain, Saramaria Afanador Castiblanco, Martin Zak, Sandra Zaeh, Ishaan Gupta, Mahendra Damarla, Naresh M. Punjabi

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

While benefits of prone position in mechanically-ventilated patients have been well-described, a randomized-control trial to determine the effects of prone positioning in awake, spontaneously-breathing patients with an acute pneumonia has not been previously conducted. Prone Position and Respiratory Outcomes in Non-Intubated COVID-19 PatiEnts: the “PRONE” Study (PRONE) was conducted in non-intubated hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia as defined by respiratory rate ≥ 20/min or an oxyhemoglobin saturation (SpO₂) ≤ 93% without supplemental oxygen [1]. The PRONE trial was designed to investigate the effects of prone positioning on need for escalation in respiratory support, as defined by need for transition to a higher acuity level of care, increased fraction of inspired oxygen (FiO₂), or the initiation of invasive mechanical ventilation. Secondary objectives were to assess the duration of effect of prone positioning on respiratory parameters such as respiratory rate and SpO₂, as well as other outcomes such as time to discharge or transition in level of care.

Original language	English (US)
Article number	106541
Journal	Contemporary Clinical Trials
Volume	109
DOIs	https://doi.org/10.1016/j.cct.2021.106541
State	Published - Oct 2021

Keywords

Awake
COVID-19
Hospitalized
Multicenter
Prone
Randomized

ASJC Scopus subject areas

Pharmacology (medical)

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10.1016/j.cct.2021.106541

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Friedman, E., Franzone, J., Ko, E. R., Corey, K., Mock, J., Alavian, N., Schwartz, A., Drummond, M. B., Suber, T., Linstrum, K., Bain, W., Castiblanco, S. A., Zak, M., Zaeh, S., Gupta, I., Damarla, M., & Punjabi, N. M. (2021). Rationale and design of the prone position and respiratory outcomes in non-intubated COVID-19 patients: The “PRONE” study. Contemporary Clinical Trials, 109, Article 106541. https://doi.org/10.1016/j.cct.2021.106541

Friedman, E, Franzone, J, Ko, ER, Corey, K, Mock, J, Alavian, N, Schwartz, A, Drummond, MB, Suber, T, Linstrum, K, Bain, W, Castiblanco, SA, Zak, M, Zaeh, S, Gupta, I , Damarla, M & Punjabi, NM 2021, 'Rationale and design of the prone position and respiratory outcomes in non-intubated COVID-19 patients: The “PRONE” study', Contemporary Clinical Trials, vol. 109, 106541. https://doi.org/10.1016/j.cct.2021.106541

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abstract = "While benefits of prone position in mechanically-ventilated patients have been well-described, a randomized-control trial to determine the effects of prone positioning in awake, spontaneously-breathing patients with an acute pneumonia has not been previously conducted. Prone Position and Respiratory Outcomes in Non-Intubated COVID-19 PatiEnts: the “PRONE” Study (PRONE) was conducted in non-intubated hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia as defined by respiratory rate ≥ 20/min or an oxyhemoglobin saturation (SpO2) ≤ 93% without supplemental oxygen [1]. The PRONE trial was designed to investigate the effects of prone positioning on need for escalation in respiratory support, as defined by need for transition to a higher acuity level of care, increased fraction of inspired oxygen (FiO2), or the initiation of invasive mechanical ventilation. Secondary objectives were to assess the duration of effect of prone positioning on respiratory parameters such as respiratory rate and SpO2, as well as other outcomes such as time to discharge or transition in level of care.",

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Rationale and design of the prone position and respiratory outcomes in non-intubated COVID-19 patients: The “PRONE” study

Abstract

Keywords

ASJC Scopus subject areas

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