Rationale and Design for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)

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Abstract

Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

Original languageEnglish (US)
Pages (from-to)568-574
Number of pages7
JournalPancreas
Volume51
Issue number6
DOIs
StatePublished - Jul 1 2022

Keywords

  • AP - acute pancreatitis
  • CP - chronic pancreatitis
  • DCC - data coordinating center
  • DM - diabetes mellitus
  • DREAM - Diabetes RElated to Acute pancreatitis and its Mechanisms
  • FSIGTT - frequently sampled intravenous glucose tolerance testing
  • MMTT - mixed meal tolerance testing
  • OGTT - oral glucose tolerance testing
  • T1DAPC - Type 1 Diabetes in Acute Pancreatitis Consortium
  • autoantibody
  • beta cell
  • epidemiology
  • insulin
  • pancreatogenic diabetes
  • type 3c diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology

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