Rational use of antibiotics for perforated appendicitis in childhood

Irving B. David, James R. Buck, Robert M. Filler

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Gangrenous and perforated appendicitis was reviewed in 300 pediatric patients. Those with only gangrene generally had a benign course regardless of whether antibiotic therapy was used. However, patients with local perforation or generalized peritonitis had a high incidence of infective complications if they were not treated with antibiotics. Children treated with ampicillin, gentamicin, and clindamycin had markedly fewer wound infections and abscesses and were able to tolerate a diet and go home sooner than those receiving ampicillin and/or gentamicin.

Original languageEnglish (US)
Pages (from-to)494-500
Number of pages7
JournalJournal of pediatric surgery
Issue number5
StatePublished - Oct 1982


  • Appendicitis

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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