@inproceedings{5576a8ff631c4777a7016ca039f193b8,
title = "Ratiometric autofluorescence lifetime imaging system standardization and application for head and neck cancer",
abstract = "Dynamic optical contrast imaging (DOCI) is a novel optical imaging technology that rapidly generates image contrast from measurements of aggregate endogenous fluorescence lifetime in a clinically meaningful field of view. Recently, our use of this system in both human ex-vivo and in-vivo specimens generated statistically significant contrast between tumor and adjacent normal tissue in biopsies taken from patients undergoing surgery for head and neck squamous cell carcinoma and primary hyperthyroidism. In this work we evaluated the components and resolution of our next-generation DOCI system. We also standardized the quantitative output of our system against the fluorescence lifetime values of three dye standards with monoexponential decay using a commercial Leica two-photon fluorescence lifetime imaging microscope. Significantly, our system continued to demonstrate clinically meaningful contrast between tissue samples with multiexponential decay in near real-time.",
keywords = "diagnostic imaging, fluorescence lifetime, head and neck cancer",
author = "Pellionisz, \{Peter A.\} and Yong Hu and Andy Moon and Khuzaima Rangwalla and Jake Pensa and \{St John\}, \{Maie A.\}",
note = "Publisher Copyright: {\textcopyright} 2019 SPIE.; Optics in Health Care and Biomedical Optics IX 2019 ; Conference date: 21-10-2019 Through 23-10-2019",
year = "2019",
doi = "10.1117/12.2537631",
language = "English (US)",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Qingming Luo and Qingming Luo and Xingde Li and Ying Gu and Yuguo Tang and Dan Zhu",
booktitle = "Optics in Health Care and Biomedical Optics IX",
}