TY - JOUR
T1 - Rat liver alcohol dehydrogenase activity
T2 - Effects of growth hormone and hypophysectomy
AU - Mezey, Esteban
AU - Potter, James J.
PY - 1979/6
Y1 - 1979/6
N2 - Previously demonstrated increases in liver alcohol dehydrogenase in experimental uremia and after stress in the rat may be mediated by hormonal changes found in these conditions. In this study, the effects of corticosteroids, GH, adrenalectomy, and hypophysectomy on the activity of liver alcohol dehydrogenase in the rat were determined. Neither the daily administration of hydrocortisone, corticosterone, or corticotropin for 6 days nor adrenalectomy had any effect on the enzyme activity. Bovine GH, administered in doses of 0.02, 0.2, 1.0, and 4 mg/100 g BW-day for 6.5 days, resulted in increases in liver alcohol dehydrogenase. A maximum increase in the enzyme activity was found after the administration of the low dose of 0.02 mg/100 g BW-day. Plasma GH was found to be elevated in rats with increased liver alcohol dehydrogenase due to uremia or after repeated stress induced by immobilization; hence, GH may play a role in the elevation of the enzyme activity in these conditions. However, hypophysectoy was found also to increase the activity of the enzyme, and the administration of GH to the hypophysectomized animals suppressed the enhanced enzyme activity. Maximum suppression was obtained after the administration of a dose of 1.0 mg/100 g BW • day. These results indicate that liver alcohol dehydrogenase activity is affected by GH as well as by other unknown factors which are altered by hypophysectomy.
AB - Previously demonstrated increases in liver alcohol dehydrogenase in experimental uremia and after stress in the rat may be mediated by hormonal changes found in these conditions. In this study, the effects of corticosteroids, GH, adrenalectomy, and hypophysectomy on the activity of liver alcohol dehydrogenase in the rat were determined. Neither the daily administration of hydrocortisone, corticosterone, or corticotropin for 6 days nor adrenalectomy had any effect on the enzyme activity. Bovine GH, administered in doses of 0.02, 0.2, 1.0, and 4 mg/100 g BW-day for 6.5 days, resulted in increases in liver alcohol dehydrogenase. A maximum increase in the enzyme activity was found after the administration of the low dose of 0.02 mg/100 g BW-day. Plasma GH was found to be elevated in rats with increased liver alcohol dehydrogenase due to uremia or after repeated stress induced by immobilization; hence, GH may play a role in the elevation of the enzyme activity in these conditions. However, hypophysectoy was found also to increase the activity of the enzyme, and the administration of GH to the hypophysectomized animals suppressed the enhanced enzyme activity. Maximum suppression was obtained after the administration of a dose of 1.0 mg/100 g BW • day. These results indicate that liver alcohol dehydrogenase activity is affected by GH as well as by other unknown factors which are altered by hypophysectomy.
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U2 - 10.1210/endo-104-6-1667
DO - 10.1210/endo-104-6-1667
M3 - Article
C2 - 221187
AN - SCOPUS:0018774735
SN - 0013-7227
VL - 104
SP - 1667
EP - 1673
JO - Endocrinology
JF - Endocrinology
IS - 6
ER -