TY - JOUR
T1 - Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated
AU - Verma, Ajay
AU - Ross, Christopher A.
AU - Verma, Divya
AU - Supattapone, Surachai
AU - Snyder, Solomon H.
PY - 1990/9
Y1 - 1990/9
N2 - Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+,Mg2+-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+,Mg2+-ATPase. Inositol 1,4,5-triphosphate1 [I(1,4,5)P3] inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+,-Mg2+-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated.
AB - Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+,Mg2+-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+,Mg2+-ATPase. Inositol 1,4,5-triphosphate1 [I(1,4,5)P3] inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+,-Mg2+-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated.
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U2 - 10.1091/mbc.1.10.781
DO - 10.1091/mbc.1.10.781
M3 - Article
C2 - 1966012
AN - SCOPUS:0025491273
SN - 1044-2030
VL - 1
SP - 781
EP - 790
JO - Molecular Biology of the Cell
JF - Molecular Biology of the Cell
IS - 10
ER -