Ras/Raf and their influence in glycolysis in colon cancer

Genetic alterations that cause the constitutive activation of Ras/Raf signaling are highly prevalent in colorectal cancers and contribute significantly to critical stages of tumor growth and invasion. While genetic analyses have firmly established the importance of this pathway in cancer, the many contributions of dysregulated Ras/Raf signaling to cancer cell phenotypes remain a topic of intensive investigation. This review will focus on recent insights into the role of Ras/Raf signaling on glucose uptake, and the consequences of altered glucose metabolism on the evolution of neoplastic cell clones. Tumor-promoting metabolic defects have suggested new strategies for anticancer therapy.