RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights

Steven D. Rhodes; Frank McCormick; Ross L. Cagan; Annette Bakker; Verena Staedtke; Ina Ly; Matthew R. Steensma; Sang Y. Lee; Carlos G. Romo; Jaishri O. Blakeley; Kavita Y. Sarin

doi:10.1016/j.jid.2023.01.043

RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights

Steven D. Rhodes, Frank McCormick, Ross L. Cagan, Annette Bakker, Verena Staedtke, Ina Ly, Matthew R. Steensma, Sang Y. Lee, Carlos G. Romo, Jaishri O. Blakeley, Kavita Y. Sarin

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Cutaneous neurofibromas (cNFs) are the most common tumor in people with the rasopathy neurofibromatosis type 1. They number in hundreds or even thousands throughout the body, and currently, there are no effective interventions to prevent or treat these skin tumors. To facilitate the identification of novel and effective therapies, essential studies including a more refined understanding of cNF biology and the role of RAS signaling and downstream effector pathways responsible for cNF initiation, growth, and maintenance are needed. This review highlights the current state of knowledge of RAS signaling in cNF pathogenesis and therapeutic development for cNF treatment.

Original language	English (US)
Pages (from-to)	1358-1368
Number of pages	11
Journal	Journal of Investigative Dermatology
Volume	143
Issue number	8
DOIs	https://doi.org/10.1016/j.jid.2023.01.043
State	Published - Aug 2023

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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Rhodes, S. D., McCormick, F., Cagan, R. L., Bakker, A., Staedtke, V., Ly, I., Steensma, M. R., Lee, S. Y., Romo, C. G., Blakeley, J. O., & Sarin, K. Y. (2023). RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights. Journal of Investigative Dermatology, 143(8), 1358-1368. https://doi.org/10.1016/j.jid.2023.01.043

Rhodes, SD, McCormick, F, Cagan, RL, Bakker, A, Staedtke, V, Ly, I, Steensma, MR, Lee, SY , Romo, CG , Blakeley, JO & Sarin, KY 2023, 'RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights', Journal of Investigative Dermatology, vol. 143, no. 8, pp. 1358-1368. https://doi.org/10.1016/j.jid.2023.01.043

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title = "RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights",

abstract = "Cutaneous neurofibromas (cNFs) are the most common tumor in people with the rasopathy neurofibromatosis type 1. They number in hundreds or even thousands throughout the body, and currently, there are no effective interventions to prevent or treat these skin tumors. To facilitate the identification of novel and effective therapies, essential studies including a more refined understanding of cNF biology and the role of RAS signaling and downstream effector pathways responsible for cNF initiation, growth, and maintenance are needed. This review highlights the current state of knowledge of RAS signaling in cNF pathogenesis and therapeutic development for cNF treatment.",

author = "Rhodes, {Steven D.} and Frank McCormick and Cagan, {Ross L.} and Annette Bakker and Verena Staedtke and Ina Ly and Steensma, {Matthew R.} and Lee, {Sang Y.} and Romo, {Carlos G.} and Blakeley, {Jaishri O.} and Sarin, {Kavita Y.}",

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year = "2023",

month = aug,

doi = "10.1016/j.jid.2023.01.043",

language = "English (US)",

volume = "143",

pages = "1358--1368",

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AU - Rhodes, Steven D.

AU - McCormick, Frank

AU - Cagan, Ross L.

AU - Bakker, Annette

AU - Staedtke, Verena

AU - Ly, Ina

AU - Steensma, Matthew R.

AU - Lee, Sang Y.

AU - Romo, Carlos G.

AU - Blakeley, Jaishri O.

AU - Sarin, Kavita Y.

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N2 - Cutaneous neurofibromas (cNFs) are the most common tumor in people with the rasopathy neurofibromatosis type 1. They number in hundreds or even thousands throughout the body, and currently, there are no effective interventions to prevent or treat these skin tumors. To facilitate the identification of novel and effective therapies, essential studies including a more refined understanding of cNF biology and the role of RAS signaling and downstream effector pathways responsible for cNF initiation, growth, and maintenance are needed. This review highlights the current state of knowledge of RAS signaling in cNF pathogenesis and therapeutic development for cNF treatment.

AB - Cutaneous neurofibromas (cNFs) are the most common tumor in people with the rasopathy neurofibromatosis type 1. They number in hundreds or even thousands throughout the body, and currently, there are no effective interventions to prevent or treat these skin tumors. To facilitate the identification of novel and effective therapies, essential studies including a more refined understanding of cNF biology and the role of RAS signaling and downstream effector pathways responsible for cNF initiation, growth, and maintenance are needed. This review highlights the current state of knowledge of RAS signaling in cNF pathogenesis and therapeutic development for cNF treatment.

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RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights

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