Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

André X.C.N. Valente; Joo H. Shin; Abhijit Sarkar; Yuan Gao

doi:10.1038/srep00256

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

André X.C.N. Valente, Joo H. Shin, Abhijit Sarkar, Yuan Gao

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory.

Original language	English (US)
Article number	256
Journal	Scientific reports
Volume	2
DOIs	https://doi.org/10.1038/srep00256
State	Published - 2012

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abstract = "An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory.",

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AU - Shin, Joo H.

AU - Sarkar, Abhijit

AU - Gao, Yuan

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AB - An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory.

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Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

Abstract

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