Rapid measurement of T1 with spatially selective pre-inversion pulses

Elliot McVeigh, Andrew Yang, Elias Zerhouni

Research output: Contribution to journalLetterpeer-review

7 Scopus citations


A method is described for rapidly obtaining a multipoint estimate of T1 from a sample that is homogeneous over a few millimeters. An image of the longitudinal recovery curve is produced through the application of successive “pre-inversion” slices that are perpendicular to the imaging slice. These pre-inversion pulses are analogous to pre-saturation pulses, but they are much thinner and the tip angle is 180°. The baseline for the recovery is measured from sections of the sample that have not been perturbed by the slice selective pre-inversion pulses. The existence of the baseline value and the lack of slice profile effects allows a quick T1 estimate (QT1) to be made with a simple linear regression algorithm. The QT1 values are found to correlate very well with T1 values measured with the scanner in “spectrometer” mode, for volumes as small as 5×5×5 mm. Possible applications are T1 estimates in homogeneous samples and tissues, and scouting the T1 range of a tissue to be measured with higher resolution volume localization techniques.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalMedical physics
Issue number1
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Rapid measurement of T1 with spatially selective pre-inversion pulses'. Together they form a unique fingerprint.

Cite this