TY - JOUR
T1 - Rapid liquid-liquid extraction of cocaine from urine for gas chromatographic-mass spectrometric analysis
AU - Garside, Diana
AU - Goldberger, Bruce A.
AU - Preston, Kenzie L.
AU - Cone, Edward J.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1997/4/25
Y1 - 1997/4/25
N2 - A novel, simple and economic liquid-liquid extraction method for isolating cocaine from urine was developed utilizing gas chromatography-mass spectrometry (GC-MS) for analysis and quantification. The use of a single nonpolar organic solvent allowed only nonpolar analytes to be extracted from the biological fluid, and consequently, no derivatization step was necessary before CC-MS analysis. Large numbers of specimens (>60) can be extracted in approximately 3 h with this procedure. The method is highly precise (C.V. <7%), accurate (>98%), sensitive (limit of detection of 5 ng/ml) and has a mean recovery of 48.8%.
AB - A novel, simple and economic liquid-liquid extraction method for isolating cocaine from urine was developed utilizing gas chromatography-mass spectrometry (GC-MS) for analysis and quantification. The use of a single nonpolar organic solvent allowed only nonpolar analytes to be extracted from the biological fluid, and consequently, no derivatization step was necessary before CC-MS analysis. Large numbers of specimens (>60) can be extracted in approximately 3 h with this procedure. The method is highly precise (C.V. <7%), accurate (>98%), sensitive (limit of detection of 5 ng/ml) and has a mean recovery of 48.8%.
KW - Cocaine
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U2 - 10.1016/S0378-4347(96)00459-8
DO - 10.1016/S0378-4347(96)00459-8
M3 - Article
C2 - 9187384
AN - SCOPUS:0031011679
SN - 1572-6495
VL - 692
SP - 61
EP - 65
JO - Journal of Chromatography B: Biomedical Applications
JF - Journal of Chromatography B: Biomedical Applications
IS - 1
ER -