TY - JOUR
T1 - Rapid detection of rifampin resistance in Mycobacterium tuberculosis isolates by heteroduplex analysis and determination of rifamycin cross-resistance in rifampin-resistant isolates
AU - Saribaş, Zeynep
AU - Kocagöz, Tanil
AU - Alp, Alpaslan
AU - Günalp, Ayfer
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Direct heteroduplex analysis and a universal heteroduplex generator assay were performed to detect rifampin resistance rapidly in Turkish Mycobacterium tuberculosis isolates. Cross-resistance to rifapentine, rifabutin, and rifalazil was investigated. A relationship between specific mutations and resistance patterns, which can guide the choice of an appropriate therapeutic regimen for tuberculosis patients, was identified.
AB - Direct heteroduplex analysis and a universal heteroduplex generator assay were performed to detect rifampin resistance rapidly in Turkish Mycobacterium tuberculosis isolates. Cross-resistance to rifapentine, rifabutin, and rifalazil was investigated. A relationship between specific mutations and resistance patterns, which can guide the choice of an appropriate therapeutic regimen for tuberculosis patients, was identified.
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U2 - 10.1128/JCM.41.2.816-818.2003
DO - 10.1128/JCM.41.2.816-818.2003
M3 - Article
C2 - 12574290
AN - SCOPUS:0037312121
SN - 0095-1137
VL - 41
SP - 816
EP - 818
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 2
ER -