TY - JOUR
T1 - Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda
AU - Gray, Ronald H.
AU - Wabwire-Mangen, Fred
AU - Kigozi, Godfrey
AU - Sewankambo, Nelson K.
AU - Serwadda, David
AU - Moulton, Lawrence H.
AU - Quinn, Thomas C.
AU - O'Brien, Katherine L.
AU - Meehan, Mary
AU - Abramowsky, Carlos
AU - Robb, Merlin
AU - Wawer, Maria J.
N1 - Funding Information:
Supported by grants RO1 AI34826 and RO1 AI3426S from the National Institute of Allergy and Infectious Diseases, grant 5P30HD06826 from National Institute of Child Health and Development, grant 5D43TW00010 from the Fogarty Foundation, National Institutes of Health, the Rockefeller Foundation, grant 5024-30 from John Snow Inc, Pfizer Inc, and the World Bank STI Project, Uganda.
PY - 2001
Y1 - 2001
N2 - OBJECTIVE: The purpose of this study was to assess presumptive sexually transmitted disease treatment on pregnancy outcome and HIV transmission. STUDY DESIGN: In a randomized trial in Rakai District, Uganda, 2070 pregnant women received presumptive sexually transmitted disease treatment 1 time during pregnancy at varying gestations, and 1963 control mothers received iron/folate and referral for syphilis. Maternal-infant sexually transmitted disease/HIV and infant outcomes were assessed. Intent-to-treat analyses estimated adjusted rate ratios and 95% confidence intervals. RESULTS: Sexually transmitted diseases were reduced: Trichomonas vaginalis (rate ratio, 0.28; 95% Cl, 0.18%-0.49%), bacterial vaginosis (rate ratio, 0.78; 95% Cl, 0.69-0.87), Neisseria gonorrhoeae/Chlamydia trachomatis (rate ratio, 0.43; 95% Cl, 0.27-0.68), and infant ophthalmia (rate ratio, 0.37; 95% Cl, 0.20-0.70). There were reduced rates of neonatal death (rate ratio, 0.83; 95% Cl, 0.71-0.97), low birth weight (rate ratio, 0.68; 95% Cl, 0.53-0.86), and preterm delivery (rate ratio, 0.77; 95% Cl, 0.56-1.05); but there were no effects on maternal HIV acquisition or perinatal HIV transmission. CONCLUSION: Reductions of maternal sexually transmitted disease improved pregnancy outcome but not maternal HIV acquisition or perinatal HIV transmission.
AB - OBJECTIVE: The purpose of this study was to assess presumptive sexually transmitted disease treatment on pregnancy outcome and HIV transmission. STUDY DESIGN: In a randomized trial in Rakai District, Uganda, 2070 pregnant women received presumptive sexually transmitted disease treatment 1 time during pregnancy at varying gestations, and 1963 control mothers received iron/folate and referral for syphilis. Maternal-infant sexually transmitted disease/HIV and infant outcomes were assessed. Intent-to-treat analyses estimated adjusted rate ratios and 95% confidence intervals. RESULTS: Sexually transmitted diseases were reduced: Trichomonas vaginalis (rate ratio, 0.28; 95% Cl, 0.18%-0.49%), bacterial vaginosis (rate ratio, 0.78; 95% Cl, 0.69-0.87), Neisseria gonorrhoeae/Chlamydia trachomatis (rate ratio, 0.43; 95% Cl, 0.27-0.68), and infant ophthalmia (rate ratio, 0.37; 95% Cl, 0.20-0.70). There were reduced rates of neonatal death (rate ratio, 0.83; 95% Cl, 0.71-0.97), low birth weight (rate ratio, 0.68; 95% Cl, 0.53-0.86), and preterm delivery (rate ratio, 0.77; 95% Cl, 0.56-1.05); but there were no effects on maternal HIV acquisition or perinatal HIV transmission. CONCLUSION: Reductions of maternal sexually transmitted disease improved pregnancy outcome but not maternal HIV acquisition or perinatal HIV transmission.
KW - Birth weight
KW - HIV
KW - Neonatal death
KW - Perinatal HIV transmission
KW - Preterm
KW - Sexually transmitted disease
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U2 - 10.1067/mob.2001.118158
DO - 10.1067/mob.2001.118158
M3 - Article
C2 - 11717659
AN - SCOPUS:0035192551
SN - 0002-9378
VL - 185
SP - 1209
EP - 1217
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 5
ER -