TY - JOUR
T1 - Randomized Double Masked Trial of Zhi Byed 11, a Tibetan Traditional Medicine, Versus Misoprostol to Prevent Postpartum Hemorrhage in Lhasa, Tibet
AU - Miller, Suellen
AU - Tudor, Carrie
AU - Thorsten, Vanessa
AU - Nyima,
AU - Kalyang,
AU - Sonam,
AU - Lhakpen,
AU - Droyoung,
AU - Quzong, Karma
AU - Dekyi, Tsering
AU - Hartwell, Ty
AU - Wright, Linda L.
AU - Varner, Michael W.
N1 - Funding Information:
This study is part of the Global Network for Women's and Children's Health Research supported by the National Institute of Child Health and Human Development (NICHD) (grant no. U01-HD40613). NICHD, under a cooperative agreement with the study team, participated in the study design, interpretation of data, and the editing and submission of the manuscript. The Bill and Melinda Gates Foundation, who also provided a grant for this research, had no direct involvement in the study. The authors gratefully acknowledge Ngawang Drolma of the Tibetan Autonomous Region Health Bureau and Dr. Dromdul, Director of the Mentzikhang Traditional Tibetan Medicine and Astrology Hospital, for their continued support and assistance to make this project possible. The authors are also indebted to the staff at the three project hospitals in Lhasa: Mentzikhang Traditional Tibetan Medicine and Astrology Hospital, Lhasa Municipal Hospital, and the Lhasa Maternal and Child Health Hospital for their work and dedication to this project. Greatest thanks to those women who participated in this study.
PY - 2009
Y1 - 2009
N2 - The objective of this study was to compare a Tibetan traditional medicine (the uterotonic Zhi Byed 11 [ZB11]) to oral misoprostol for prophylaxis of postpartum hemorrhage (PPH). We conducted a double-blind randomized controlled trial at three hospitals in Lhasa, Tibet, People's Republic of China. Women (N = 967) were randomized to either ZB11 or misoprostol groups. Postpartum blood loss was measured in a calibrated blood collection drape. The primary combined outcome was incidence of PPH, defined as measured blood loss (MBL) ≥ 500 mL, administration of open label uterotonics, or maternal death. We found that the rate of the combined outcome was lower among the misoprostol group (16.1% versus 21.8% for ZB11; P = .02). Frequency of PPH was lower with misoprostol (12.4% versus 17.4%; P = .02). There were no significant differences in MBL > 1000 mL or mean or median MBL. Fever was significantly more common in the misoprostol group (P = .03). The rate of combined outcome was significantly lower among women receiving misoprostol. However, other indices of obstetric hemorrhage were not significantly different.
AB - The objective of this study was to compare a Tibetan traditional medicine (the uterotonic Zhi Byed 11 [ZB11]) to oral misoprostol for prophylaxis of postpartum hemorrhage (PPH). We conducted a double-blind randomized controlled trial at three hospitals in Lhasa, Tibet, People's Republic of China. Women (N = 967) were randomized to either ZB11 or misoprostol groups. Postpartum blood loss was measured in a calibrated blood collection drape. The primary combined outcome was incidence of PPH, defined as measured blood loss (MBL) ≥ 500 mL, administration of open label uterotonics, or maternal death. We found that the rate of the combined outcome was lower among the misoprostol group (16.1% versus 21.8% for ZB11; P = .02). Frequency of PPH was lower with misoprostol (12.4% versus 17.4%; P = .02). There were no significant differences in MBL > 1000 mL or mean or median MBL. Fever was significantly more common in the misoprostol group (P = .03). The rate of combined outcome was significantly lower among women receiving misoprostol. However, other indices of obstetric hemorrhage were not significantly different.
KW - complementary medicine
KW - obstetric hemorrhage
KW - postpartum hemorrhage
KW - randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=60649089263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60649089263&partnerID=8YFLogxK
U2 - 10.1016/j.jmwh.2008.09.010
DO - 10.1016/j.jmwh.2008.09.010
M3 - Article
C2 - 19249659
AN - SCOPUS:60649089263
SN - 1526-9523
VL - 54
SP - 133
EP - 141
JO - Journal of Midwifery and Women's Health
JF - Journal of Midwifery and Women's Health
IS - 2
ER -