Randomized controlled trial of hospital-based hygiene and water treatment intervention (CHoBI7) to reduce cholera

Christine Marie George, Shirajum Monira, David A. Sack, Mahamud Ur Rashid, K. M. Saif-Ur-Rahman, Toslim Mahmud, Zillur Rahman, Munshi Mustafiz, Sazzadul Islam Bhuyian, Peter J. Winch, Elli Leontsini, Jamie Perin, Farzana Begum, Fatema Zohura, Shwapon Biswas, Tahmina Parvin, Xiaotong Zhang, Danielle Jung, R. Bradley Sack, Munirul Alam

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which promotes hand washing with soap and treatment of water. To test CHoBI7, we conducted a randomized controlled trial among 219 intervention household contacts of 82 cholera patients and 220 control contacts of 83 cholera patients in Dhaka, Bangladesh, during 2013-2014. Intervention contacts had signifi- cantly fewer symptomatic Vibrio cholerae infections than did control contacts and 47% fewer overall V. cholerae infections. Intervention households had no stored drinking water with V. cholerae and 14 times higher odds of hand washing with soap at key events during structured observation on surveillance days 5, 6, or 7. CHoBI7 presents a promising approach for controlling cholera among highly susceptible household contacts of cholera patients.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalEmerging infectious diseases
Issue number2
StatePublished - Feb 2016

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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