TY - JOUR
T1 - Randomized clinical trial of perioperative cefoxitin in preventing maternal infection after primary cesarean section
AU - Frank Polk, B.
AU - Krache, Martha
AU - Phillippe, Mark
AU - Munoz, Alvaro
AU - Hutchinson, Denise
AU - Miao, Lillian
AU - Schoenbaum, Stephen C.
N1 - Funding Information:
This study was funded by Merck Shaq and Dohme.
PY - 1982/4/15
Y1 - 1982/4/15
N2 - To determine the efficacy of perioperative cefoxitin in preventing infections after primary cesarean section, a randomized placebo-controlled, double-blind clinical trial was performed. Among 266 participants, those who received three perioperative 2 gm doses of cefoxitin (138) had significantly fewer serious infections (19.5% vs. 4.3%), fewer urinary tract infections (10.7% vs. 4.4%), less standard febrile morbidity (9.4% vs. 3.6%), and fewer courses of antibiotics postoperatively (23.4% vs. 11.6%). There was no reduction in the length of hospitalization. Use of perioperative cefoxitin was not accompanied by more side effects. Three doses of cefoxitin beginning as soon as the umbilical cord is clamped are safe and efficacious in preventing infection after primary cesarean section.
AB - To determine the efficacy of perioperative cefoxitin in preventing infections after primary cesarean section, a randomized placebo-controlled, double-blind clinical trial was performed. Among 266 participants, those who received three perioperative 2 gm doses of cefoxitin (138) had significantly fewer serious infections (19.5% vs. 4.3%), fewer urinary tract infections (10.7% vs. 4.4%), less standard febrile morbidity (9.4% vs. 3.6%), and fewer courses of antibiotics postoperatively (23.4% vs. 11.6%). There was no reduction in the length of hospitalization. Use of perioperative cefoxitin was not accompanied by more side effects. Three doses of cefoxitin beginning as soon as the umbilical cord is clamped are safe and efficacious in preventing infection after primary cesarean section.
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U2 - 10.1016/0002-9378(82)90779-7
DO - 10.1016/0002-9378(82)90779-7
M3 - Article
C2 - 7041652
AN - SCOPUS:0020024893
SN - 0002-9378
VL - 142
SP - 983
EP - 987
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 8
ER -