Radiosynthesis of (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[11C]‐methyI‐l,2,3,4‐tetrahydro‐isoquinoline, [11C]A‐69024: A non‐benzazepine antagonist for studying dopamine D1 receptors In vivo using PET

Michael Kassiou; William B. Mathews; John L. Musachio; Hayden T. Ravert; Richard M. Lambrecht; Robert F. Dannals

doi:10.1002/jlcr.2580340505

Radiosynthesis of (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[¹¹C]‐methyI‐l,2,3,4‐tetrahydro‐isoquinoline, [¹¹C]A‐69024: A non‐benzazepine antagonist for studying dopamine D1 receptors In vivo using PET

Michael Kassiou, William B. Mathews, John L. Musachio, Hayden T. Ravert, Richard M. Lambrecht, Robert F. Dannals

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

(±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[¹¹C]‐methyl‐1,2,3,4‐tetrahydroisoquinoline, (HCJA‐69024, a selective ligand for the D1 receptor was prepared by N‐alkylation of (±)N‐desmethyl A‐69024 with [¹¹C]methyl iodide in DMF. The radiotracer was purified by semi‐preparative reverse‐phase HPLC. The average specific activity was 1950 mCi/μmol calculated at end‐of‐synthesis (EOS). The average time of synthesis including formulation was 20 minutes.

Original language	English (US)
Pages (from-to)	431-437
Number of pages	7
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	34
Issue number	5
DOIs	https://doi.org/10.1002/jlcr.2580340505
State	Published - May 1994

Keywords

A‐69024
PET
carbon‐11
dopamine D1 receptor
radiotracer

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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Kassiou, M., Mathews, W. B., Musachio, J. L., Ravert, H. T., Lambrecht, R. M., & Dannals, R. F. (1994). Radiosynthesis of (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[¹¹C]‐methyI‐l,2,3,4‐tetrahydro‐isoquinoline, [¹¹C]A‐69024: A non‐benzazepine antagonist for studying dopamine D1 receptors In vivo using PET. Journal of Labelled Compounds and Radiopharmaceuticals, 34(5), 431-437. https://doi.org/10.1002/jlcr.2580340505

Radiosynthesis of (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[¹¹C]‐methyI‐l,2,3,4‐tetrahydro‐isoquinoline, [¹¹C]A‐69024: A non‐benzazepine antagonist for studying dopamine D1 receptors In vivo using PET. / Kassiou, Michael; Mathews, William B.; Musachio, John L. et al.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 34, No. 5, 05.1994, p. 431-437.

Research output: Contribution to journal › Article › peer-review

Kassiou, M, Mathews, WB, Musachio, JL, Ravert, HT, Lambrecht, RM & Dannals, RF 1994, 'Radiosynthesis of (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[¹¹C]‐methyI‐l,2,3,4‐tetrahydro‐isoquinoline, [¹¹C]A‐69024: A non‐benzazepine antagonist for studying dopamine D1 receptors In vivo using PET', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 34, no. 5, pp. 431-437. https://doi.org/10.1002/jlcr.2580340505

Kassiou M, Mathews WB, Musachio JL, Ravert HT, Lambrecht RM, Dannals RF. Radiosynthesis of (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[¹¹C]‐methyI‐l,2,3,4‐tetrahydro‐isoquinoline, [¹¹C]A‐69024: A non‐benzazepine antagonist for studying dopamine D1 receptors In vivo using PET. Journal of Labelled Compounds and Radiopharmaceuticals. 1994 May;34(5):431-437. doi: 10.1002/jlcr.2580340505

Kassiou, Michael ; Mathews, William B. ; Musachio, John L. et al. / Radiosynthesis of (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[¹¹C]‐methyI‐l,2,3,4‐tetrahydro‐isoquinoline, [¹¹C]A‐69024 : A non‐benzazepine antagonist for studying dopamine D1 receptors In vivo using PET. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1994 ; Vol. 34, No. 5. pp. 431-437.

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