TY - JOUR
T1 - Radiosurgery reirradiation for high-grade glioma recurrence
T2 - a retrospective analysis
AU - Pinzi, Valentina
AU - Orsi, Chiara
AU - Marchetti, Marcello
AU - Milanesi, Ida Maddalena
AU - Bianchi, Livia Corinna
AU - DiMeco, Francesco
AU - Cuccarini, Valeria
AU - Farinotti, Mariangela
AU - Ferroli, Paolo
AU - Finocchiaro, Gaetano
AU - Franzini, Angelo
AU - Fumagalli, MariaLuisa L.
AU - Silvani, Antonio
AU - Fariselli, Laura
PY - 2015/8/28
Y1 - 2015/8/28
N2 - Despite various treatment strategies being available, recurrent high-grade gliomas (r-HGG) are difficult to manage. To obtain local control, radiosurgery (SRS) reirradiation has been considered as potential treatment. In the present study, a retrospective analysis was performed on r-HGG patients treated with salvage single- (s-SRS) or multi-fraction SRS (m-SRS). The aim of this study was to evaluate the effectiveness of salvage SRS in terms of overall survival (OS); toxicity was analyzed as well. Between 2004 May and 2011 December, 128 r-HGG patients (161 lesions) treated with CyberKnife® SRS reirradiation were retrospectively analyzed. Toxicity was graded according to Radiation Therapy Oncology Group and by Common Terminology Criteria for Adverse Events v.3 criteria. OS from the diagnosis date and OS from reirradiation were estimated using the Kaplan–Meier method. Median follow-up was 9 months (range 15 days–82 months). All patients completed SRS without high-grade toxicity. Radiation necrosis was observed in seven patients (6 %) with large volume lesions. The median survival from initial diagnosis was 32 months. The 1-, 2-, and 3-years survival rates from diagnosis were 95, 62, and 45 % respectively. Median survival following SRS was 11.5 months. The 1-, 2-, and 3-years survival rate following SRS was 48, 20, and 17 % respectively. On multivariate analysis, age
AB - Despite various treatment strategies being available, recurrent high-grade gliomas (r-HGG) are difficult to manage. To obtain local control, radiosurgery (SRS) reirradiation has been considered as potential treatment. In the present study, a retrospective analysis was performed on r-HGG patients treated with salvage single- (s-SRS) or multi-fraction SRS (m-SRS). The aim of this study was to evaluate the effectiveness of salvage SRS in terms of overall survival (OS); toxicity was analyzed as well. Between 2004 May and 2011 December, 128 r-HGG patients (161 lesions) treated with CyberKnife® SRS reirradiation were retrospectively analyzed. Toxicity was graded according to Radiation Therapy Oncology Group and by Common Terminology Criteria for Adverse Events v.3 criteria. OS from the diagnosis date and OS from reirradiation were estimated using the Kaplan–Meier method. Median follow-up was 9 months (range 15 days–82 months). All patients completed SRS without high-grade toxicity. Radiation necrosis was observed in seven patients (6 %) with large volume lesions. The median survival from initial diagnosis was 32 months. The 1-, 2-, and 3-years survival rates from diagnosis were 95, 62, and 45 % respectively. Median survival following SRS was 11.5 months. The 1-, 2-, and 3-years survival rate following SRS was 48, 20, and 17 % respectively. On multivariate analysis, age
KW - Multi-fraction radiosurgery
KW - Recurrent high-grade glioma
KW - Reirradiation
KW - Single-fraction radiosurgery
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U2 - 10.1007/s10072-015-2172-7
DO - 10.1007/s10072-015-2172-7
M3 - Article
C2 - 25805705
AN - SCOPUS:84938200893
SN - 1590-1874
VL - 36
SP - 1431
EP - 1440
JO - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
IS - 8
ER -