Radiosurgery reirradiation for high-grade glioma recurrence: a retrospective analysis

Valentina Pinzi, Chiara Orsi, Marcello Marchetti, Ida Maddalena Milanesi, Livia Corinna Bianchi, Francesco DiMeco, Valeria Cuccarini, Mariangela Farinotti, Paolo Ferroli, Gaetano Finocchiaro, Angelo Franzini, MariaLuisa L. Fumagalli, Antonio Silvani, Laura Fariselli

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Despite various treatment strategies being available, recurrent high-grade gliomas (r-HGG) are difficult to manage. To obtain local control, radiosurgery (SRS) reirradiation has been considered as potential treatment. In the present study, a retrospective analysis was performed on r-HGG patients treated with salvage single- (s-SRS) or multi-fraction SRS (m-SRS). The aim of this study was to evaluate the effectiveness of salvage SRS in terms of overall survival (OS); toxicity was analyzed as well. Between 2004 May and 2011 December, 128 r-HGG patients (161 lesions) treated with CyberKnife® SRS reirradiation were retrospectively analyzed. Toxicity was graded according to Radiation Therapy Oncology Group and by Common Terminology Criteria for Adverse Events v.3 criteria. OS from the diagnosis date and OS from reirradiation were estimated using the Kaplan–Meier method. Median follow-up was 9 months (range 15 days–82 months). All patients completed SRS without high-grade toxicity. Radiation necrosis was observed in seven patients (6 %) with large volume lesions. The median survival from initial diagnosis was 32 months. The 1-, 2-, and 3-years survival rates from diagnosis were 95, 62, and 45 % respectively. Median survival following SRS was 11.5 months. The 1-, 2-, and 3-years survival rate following SRS was 48, 20, and 17 % respectively. On multivariate analysis, age

Original languageEnglish (US)
Pages (from-to)1431-1440
Number of pages10
JournalNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Issue number8
StatePublished - Aug 28 2015
Externally publishedYes


  • Multi-fraction radiosurgery
  • Recurrent high-grade glioma
  • Reirradiation
  • Single-fraction radiosurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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