Radiosensitization by a modified nucleotide that produces DNA interstrand cross-links under hypoxie conditions

In Seok Hong, Hui Ding, Marc M. Greenberg

Research output: Contribution to journalArticlepeer-review

Abstract

This paper describes the reactivity of a molecule that combines two desirable chemical processes into one molecule for the first time. Interstrand cross-links (ISCs) are an effective family of lesions produced by cytotoxic agents that target DNA. For instance, ISCs are the source of mitomycin C's cytotoxicity. Radiosensitizing agents are molecules that enhance DNA damage produced by ionizing radiation, especially under O2-deficient conditions. Phenyl selenide 1 is the first example of a modified nucleotide that can be incorporated in DNA by polymerases, which produces ISCs when DNA containing it is exposed to γ-radiolysis under O2-deficient conditions. These experiments suggest that 1 could be useful as a novel type of radiosensitizing agent.

Original languageEnglish (US)
Pages (from-to)2230-2231
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number7
DOIs
StatePublished - Feb 22 2006

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry

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