Abstract
Twelve dogs with allografted lungs were treated with azathioprine and rabbit antidog thymocyte serum. Chest roentgenography, pulmonary angiography, and lung biopsy revealed a dissociation of the alveolar and vascular components of rejection in 7 of the animals. The vascular phase of rejection was more effectively suppressed than the alveolar phase. This dissociation may produce a functional disturbance with a decreased ventilation to perfusion ratio within the allograft such as has been observed in human lung transplant recipients. The results of this investigation suggest that rejection plays a more important role than previously recognized in the ventilation-perfusion imbalance that occurs with pulmonary allografts.
Original language | English (US) |
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Pages (from-to) | 127-138 |
Number of pages | 12 |
Journal | Annals of Thoracic Surgery |
Volume | 12 |
Issue number | 2 |
DOIs | |
State | Published - 1971 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine