Radioiodination via vinylstannylated alkylating agents

John L. Musachio, John R. Lever

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

p-Toluenesulfonate esters of (E)- and (Z)-3-(tri-n-butylstannyl)-2-propen-1-ol readily react with nucleophiles to give vinylstannanes which are substrates for rapid, efficient and stereospecific radioiododestannylation at the no-carrier-added level. This general approach is illustrated by syntheses of iodinated spiperone analogs for studies of dopamine D2 receptors.

Original languageEnglish (US)
Pages (from-to)3613-3616
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number28
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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