Abstract
p-Toluenesulfonate esters of (E)- and (Z)-3-(tri-n-butylstannyl)-2-propen-1-ol readily react with nucleophiles to give vinylstannanes which are substrates for rapid, efficient and stereospecific radioiododestannylation at the no-carrier-added level. This general approach is illustrated by syntheses of iodinated spiperone analogs for studies of dopamine D2 receptors.
Original language | English (US) |
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Pages (from-to) | 3613-3616 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 30 |
Issue number | 28 |
DOIs | |
State | Published - 1989 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry