TY - JOUR
T1 - Radioimmunotherapy is effective against high-inoculum cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells
AU - Bryan, Ruth A.
AU - Jiang, Zewei
AU - Huang, Xianchun
AU - Morgenstern, Alfred
AU - Bruchertseifer, Frank
AU - Sellers, Rani
AU - Casadevall, Arturo
AU - Dadachova, Ekaterina
PY - 2009/4
Y1 - 2009/4
N2 - We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.
AB - We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.
UR - http://www.scopus.com/inward/record.url?scp=65649121945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65649121945&partnerID=8YFLogxK
U2 - 10.1128/AAC.01334-08
DO - 10.1128/AAC.01334-08
M3 - Article
C2 - 19139285
AN - SCOPUS:65649121945
SN - 0066-4804
VL - 53
SP - 1679
EP - 1682
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 4
ER -