Radioembolization with 90Y microspheres: Angiographic and technical considerations

Robert J. Lewandowski, Kent T. Sato, Bassel Atassi, Robert K. Ryu, Albert A. Nemcek, Laura Kulik, Jean Francois Geschwind, Ravi Murthy, William Rilling, David Liu, Lourens Bester, Jose Ignacio Bilbao, Andrew S. Kennedy, Reed A. Omary, Riad Salem

Research output: Contribution to journalReview articlepeer-review

211 Scopus citations


The anatomy of the mesenteric system and the hepatic arterial bed has been demonstrated to have a high degree of variation. This is important when considering pre-surgical planning, catheterization, and trans-arterial hepatic therapies. Although anatomical variants have been well described, the characterization and understanding of regional hepatic perfusion in the context of radioembolization have not been studied with great depth. The purpose of this review is to provide a thorough discussion and detailed presentation of the angiographic and technical aspects of radioembolization. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. Furthermore, the principles described here apply to all liver-directed transarterial therapies.

Original languageEnglish (US)
Pages (from-to)571-592
Number of pages22
JournalCardiovascular and interventional radiology
Issue number4
StatePublished - Jul 2007


  • Brachytherapy
  • Embolization
  • Liver cancer
  • Radioembolization
  • SIR-Spheres
  • Selective internal radiation
  • TheraSphere
  • Yttrium-90

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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