Radical surgical cytoreduction of progressive leiomyomatosis peritonealis disseminata: A case report

Katherine Goodrich Kratz, Antonio Santillan, Mai Gu, Robert E. Bristow

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


BACKGROUND: Leiomyomatosis peritonealis disseminata (LPD) is an uncommon, benign smooth muscle condition of the peritoneal cavity that appears clinically as a metastatic malignant neoplasm. Generally, radical surgery is not recommended. This unique case involves curative radical surgery after disease progression during depo-medroxyprogesterone acetate therapy. In vitro assays and future implications are discussed. CASE: A 31-year-old woman presented with abdominal pain and uterine leiomyomas. During exploratory laparotomy, she had gross evidence of LPD. Despite initial surgery and hormonal therapy, she had progression of disease. She then underwent optimal cytoreductive surgery. Tumor response to megestrol acetate in vitro was evaluated and noted to be heterogeneous; therefore it was not given as adjuvant therapy. Five years after radical surgery, she was without evidence of disease. CONCLUSION: Radical secondary cytoreductive surgery can achieve a durable remission for LPD refractory to primary surgical castration and depomedroxyprogesterone acetate therapy.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number7
StatePublished - Jul 2009


  • Depo-medroxyprogesterone acetate
  • Hormonal therapy
  • Leiomyomatosis peritonealis disseminata
  • Megestrol acetate
  • Radical surgical cytoreduction

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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