Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas

Donald E. Thrall; Deborah M. Prescott; Thaddeus V. Samulski; Gary L. Rosner; David L. Denman; Roberto L. Legorreta; Richard K. Dodge; Rodney L. Page; J. Mark Cline; Jihjong Lee; Beth C. Case; Sydney M. Evans; James R. Oleson; Mark W. Dewhirst

doi:10.1016/0360-3016(95)02260-0

Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas

Donald E. Thrall, Deborah M. Prescott, Thaddeus V. Samulski, Gary L. Rosner, David L. Denman, Roberto L. Legorreta, Richard K. Dodge, Rodney L. Page, J. Mark Cline, Jihjong Lee, Beth C. Case, Sydney M. Evans, James R. Oleson, Mark W. Dewhirst

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Purpose: The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. Methods and Materials: Dogs with spontaneous soft tissue sarcomas and no evidence of metastasis were randomized to be treated with radiation combined with either LH alone or LH + WBH. Dogs were accessioned for treatment at two institutions. The radiation dose was 56.25 Gy, given in 25 2.25 Gy daily fractions. Two hyperthermia treatments were given; one during the first and one during the last week of treatment. Dogs were evaluated after treatment for local recurrence, metastasis, and complications. Results: Sixty-four dogs were treated between 1989 and 1993. The use of LH+WBH resulted in statistically significant increases in the low and middle regions of the temperature distributions. The largest increase was in the low temperatures with median CEM 43 T90 values of 4 vs. 49 min for LH vs. LH + WBH, respectively (p < 0.001). There was no difference in duration of local tumor control between hyperthermia groups (p = 0.59). The time to metastasis was shorter for dogs receiving LH + WBH (p = 0.02); the hazard ratio for metastatic disease for dogs in the LH + WBH group was 2.5 (95% confidence interval, 1.2-5.4) with respect to dogs in the LH group. Complications were greater in larger tumors and in tumors treated with LH + WBH. Conclusion: The combination of LH + WBH with radiation therapy, as described herein, was not associated with an increase in local tumor control in comparison to use of LH with radiation therapy. The combination of LH + WBH also appeared to alter the biology of the metastatic process and was associated with more complications than LH. We identified no rationale for further study of LH + WBH in combination with radiation for treatment of solid tumors.

Original language	English (US)
Pages (from-to)	1087-1096
Number of pages	10
Journal	International Journal of Radiation Oncology Biology Physics
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/0360-3016(95)02260-0
State	Published - Mar 15 1996
Externally published	Yes

Keywords

Canine sarcomas
Local hyperthermia
Radiation
Whole-body hyperthermia

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(95)02260-0

Cite this

Thrall, D. E., Prescott, D. M., Samulski, T. V., Rosner, G. L., Denman, D. L., Legorreta, R. L., Dodge, R. K., Page, R. L., Cline, J. M., Lee, J., Case, B. C., Evans, S. M., Oleson, J. R., & Dewhirst, M. W. (1996). Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas. International Journal of Radiation Oncology Biology Physics, 34(5), 1087-1096. https://doi.org/10.1016/0360-3016(95)02260-0

Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas. / Thrall, Donald E.; Prescott, Deborah M.; Samulski, Thaddeus V. et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 34, No. 5, 15.03.1996, p. 1087-1096.

Research output: Contribution to journal › Article › peer-review

Thrall, DE, Prescott, DM, Samulski, TV, Rosner, GL, Denman, DL, Legorreta, RL, Dodge, RK, Page, RL, Cline, JM, Lee, J, Case, BC, Evans, SM, Oleson, JR & Dewhirst, MW 1996, 'Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas', International Journal of Radiation Oncology Biology Physics, vol. 34, no. 5, pp. 1087-1096. https://doi.org/10.1016/0360-3016(95)02260-0

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title = "Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas",

abstract = "Purpose: The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. Methods and Materials: Dogs with spontaneous soft tissue sarcomas and no evidence of metastasis were randomized to be treated with radiation combined with either LH alone or LH + WBH. Dogs were accessioned for treatment at two institutions. The radiation dose was 56.25 Gy, given in 25 2.25 Gy daily fractions. Two hyperthermia treatments were given; one during the first and one during the last week of treatment. Dogs were evaluated after treatment for local recurrence, metastasis, and complications. Results: Sixty-four dogs were treated between 1989 and 1993. The use of LH+WBH resulted in statistically significant increases in the low and middle regions of the temperature distributions. The largest increase was in the low temperatures with median CEM 43 T90 values of 4 vs. 49 min for LH vs. LH + WBH, respectively (p < 0.001). There was no difference in duration of local tumor control between hyperthermia groups (p = 0.59). The time to metastasis was shorter for dogs receiving LH + WBH (p = 0.02); the hazard ratio for metastatic disease for dogs in the LH + WBH group was 2.5 (95% confidence interval, 1.2-5.4) with respect to dogs in the LH group. Complications were greater in larger tumors and in tumors treated with LH + WBH. Conclusion: The combination of LH + WBH with radiation therapy, as described herein, was not associated with an increase in local tumor control in comparison to use of LH with radiation therapy. The combination of LH + WBH also appeared to alter the biology of the metastatic process and was associated with more complications than LH. We identified no rationale for further study of LH + WBH in combination with radiation for treatment of solid tumors.",

keywords = "Canine sarcomas, Local hyperthermia, Radiation, Whole-body hyperthermia",

author = "Thrall, {Donald E.} and Prescott, {Deborah M.} and Samulski, {Thaddeus V.} and Rosner, {Gary L.} and Denman, {David L.} and Legorreta, {Roberto L.} and Dodge, {Richard K.} and Page, {Rodney L.} and Cline, {J. Mark} and Jihjong Lee and Case, {Beth C.} and Evans, {Sydney M.} and Oleson, {James R.} and Dewhirst, {Mark W.}",

note = "Funding Information: There are considerabled ata from in vitro and in viva studies that support the use of hyperthetia as an adjunct to radiation for treatment of solid tumors (9, 16, 20, 40). There are also data from large animal and human trials where tumor responset o radiation and hyperthetia was better than tu- Presented at the 15th Annual Meeting of the North American Hyperthermia Society, San Jose, CA, April l-6, 1995. Reprint requests to: Donald E. Thrall, D.V.M., Ph.D., College of Veterinary Medicine, North Carolina State University, 4700 mor responset o radiation alone (4, 8, 14, 19, 33, 40, 41, 5 1,54). Despite these favorable data, there are several questions that must be resolved before the optimal clinical use of hypertbermia can be realized. These problems include: (a) limitations that prohibit effective heating of many tumors, particularly large, deeply seated, or highly perfused tumors; (b) difficulty in defining a thermal dose that ade- Hillsborough Street, Raleigh, NC. Acknowledgements-This work was supported in part by grant CA42745. Accepted for publication 27 November 1995.",

year = "1996",

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day = "15",

doi = "10.1016/0360-3016(95)02260-0",

language = "English (US)",

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pages = "1087--1096",

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T1 - Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas

AU - Thrall, Donald E.

AU - Prescott, Deborah M.

AU - Samulski, Thaddeus V.

AU - Rosner, Gary L.

AU - Denman, David L.

AU - Legorreta, Roberto L.

AU - Dodge, Richard K.

AU - Page, Rodney L.

AU - Cline, J. Mark

AU - Lee, Jihjong

AU - Case, Beth C.

AU - Evans, Sydney M.

AU - Oleson, James R.

AU - Dewhirst, Mark W.

N1 - Funding Information: There are considerabled ata from in vitro and in viva studies that support the use of hyperthetia as an adjunct to radiation for treatment of solid tumors (9, 16, 20, 40). There are also data from large animal and human trials where tumor responset o radiation and hyperthetia was better than tu- Presented at the 15th Annual Meeting of the North American Hyperthermia Society, San Jose, CA, April l-6, 1995. Reprint requests to: Donald E. Thrall, D.V.M., Ph.D., College of Veterinary Medicine, North Carolina State University, 4700 mor responset o radiation alone (4, 8, 14, 19, 33, 40, 41, 5 1,54). Despite these favorable data, there are several questions that must be resolved before the optimal clinical use of hypertbermia can be realized. These problems include: (a) limitations that prohibit effective heating of many tumors, particularly large, deeply seated, or highly perfused tumors; (b) difficulty in defining a thermal dose that ade- Hillsborough Street, Raleigh, NC. Acknowledgements-This work was supported in part by grant CA42745. Accepted for publication 27 November 1995.

PY - 1996/3/15

Y1 - 1996/3/15

N2 - Purpose: The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. Methods and Materials: Dogs with spontaneous soft tissue sarcomas and no evidence of metastasis were randomized to be treated with radiation combined with either LH alone or LH + WBH. Dogs were accessioned for treatment at two institutions. The radiation dose was 56.25 Gy, given in 25 2.25 Gy daily fractions. Two hyperthermia treatments were given; one during the first and one during the last week of treatment. Dogs were evaluated after treatment for local recurrence, metastasis, and complications. Results: Sixty-four dogs were treated between 1989 and 1993. The use of LH+WBH resulted in statistically significant increases in the low and middle regions of the temperature distributions. The largest increase was in the low temperatures with median CEM 43 T90 values of 4 vs. 49 min for LH vs. LH + WBH, respectively (p < 0.001). There was no difference in duration of local tumor control between hyperthermia groups (p = 0.59). The time to metastasis was shorter for dogs receiving LH + WBH (p = 0.02); the hazard ratio for metastatic disease for dogs in the LH + WBH group was 2.5 (95% confidence interval, 1.2-5.4) with respect to dogs in the LH group. Complications were greater in larger tumors and in tumors treated with LH + WBH. Conclusion: The combination of LH + WBH with radiation therapy, as described herein, was not associated with an increase in local tumor control in comparison to use of LH with radiation therapy. The combination of LH + WBH also appeared to alter the biology of the metastatic process and was associated with more complications than LH. We identified no rationale for further study of LH + WBH in combination with radiation for treatment of solid tumors.

AB - Purpose: The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. Methods and Materials: Dogs with spontaneous soft tissue sarcomas and no evidence of metastasis were randomized to be treated with radiation combined with either LH alone or LH + WBH. Dogs were accessioned for treatment at two institutions. The radiation dose was 56.25 Gy, given in 25 2.25 Gy daily fractions. Two hyperthermia treatments were given; one during the first and one during the last week of treatment. Dogs were evaluated after treatment for local recurrence, metastasis, and complications. Results: Sixty-four dogs were treated between 1989 and 1993. The use of LH+WBH resulted in statistically significant increases in the low and middle regions of the temperature distributions. The largest increase was in the low temperatures with median CEM 43 T90 values of 4 vs. 49 min for LH vs. LH + WBH, respectively (p < 0.001). There was no difference in duration of local tumor control between hyperthermia groups (p = 0.59). The time to metastasis was shorter for dogs receiving LH + WBH (p = 0.02); the hazard ratio for metastatic disease for dogs in the LH + WBH group was 2.5 (95% confidence interval, 1.2-5.4) with respect to dogs in the LH group. Complications were greater in larger tumors and in tumors treated with LH + WBH. Conclusion: The combination of LH + WBH with radiation therapy, as described herein, was not associated with an increase in local tumor control in comparison to use of LH with radiation therapy. The combination of LH + WBH also appeared to alter the biology of the metastatic process and was associated with more complications than LH. We identified no rationale for further study of LH + WBH in combination with radiation for treatment of solid tumors.

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KW - Local hyperthermia

KW - Radiation

KW - Whole-body hyperthermia

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Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas

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Keywords

ASJC Scopus subject areas

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