TY - JOUR
T1 - Radiation necrosis of the mandible
T2 - A 10 year study. Part I. Factors influencing the onset of necrosis
AU - Murray, Christopher G.
AU - Herson, Jay
AU - Daly, Thomas E.
AU - Zimmerman, Stuart
N1 - Funding Information:
tDr. Thomas E. Daly died November 7. 1979. Reprint requests to: Dr. Christopher G. Murray, Dental Unit, Cancer institute. Peter MacCallum Hospital, Melbourne 3000. Australia. Accepted for publication 23 January 1980. This research was supported in part by Grant CA 11430 and Contract NOI-CN-75175 National Cancer Institute.
PY - 1980/5
Y1 - 1980/5
N2 - Of 404 patients who were irradiated for cancer in the oral region between 1971 and 1975, 19.1 % developed radiation necrosis of the mandible. Three main effects, anatomic tumor site, tumor dose, and dental status, were found to have a statistically significant effect on incidence of necrosis. Necrosis was also found to occur more frequently in association with an implant than with treatment administered by an external radiation source alone. The T-stage of the tumor did not appear to affect the incidence of necrosis. Necrosis incidence was also studied over two time periods- 1966-1%9 (study I) and 1971-1975 (study II). Differences between the two periods were found in the primary etiological groupings. Necrosis attributed to spontaneous or unknown cause increased in the second study, while that associated with dental extractions before irradiation decreased. Fewer teeth were extracted before radiation therapy in study If than in study 1. Less necrosis followed mandibular surgery for recurrent disease in study II than study 1.
AB - Of 404 patients who were irradiated for cancer in the oral region between 1971 and 1975, 19.1 % developed radiation necrosis of the mandible. Three main effects, anatomic tumor site, tumor dose, and dental status, were found to have a statistically significant effect on incidence of necrosis. Necrosis was also found to occur more frequently in association with an implant than with treatment administered by an external radiation source alone. The T-stage of the tumor did not appear to affect the incidence of necrosis. Necrosis incidence was also studied over two time periods- 1966-1%9 (study I) and 1971-1975 (study II). Differences between the two periods were found in the primary etiological groupings. Necrosis attributed to spontaneous or unknown cause increased in the second study, while that associated with dental extractions before irradiation decreased. Fewer teeth were extracted before radiation therapy in study If than in study 1. Less necrosis followed mandibular surgery for recurrent disease in study II than study 1.
KW - Dental oncology
KW - Head and neck cancer
KW - Mandible
KW - Osteoradionecrosis
KW - Radiotherapy complications
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U2 - 10.1016/0360-3016(80)90380-6
DO - 10.1016/0360-3016(80)90380-6
M3 - Article
C2 - 7410128
AN - SCOPUS:0018823390
SN - 0360-3016
VL - 6
SP - 543
EP - 548
JO - International journal of radiation oncology, biology, physics
JF - International journal of radiation oncology, biology, physics
IS - 5
ER -