TY - JOUR
T1 - Racial differences in HLA class II associations with hepatitis C virus outcomes
AU - Thio, Chloe L.
AU - Thomas, David L.
AU - Goedert, James J.
AU - Vlahov, David
AU - Nelson, Kenrad E.
AU - Hilgartner, Margaret W.
AU - O'Brien, Stephen J.
AU - Karacki, Peter
AU - Marti, Darlene
AU - Astemborski, Jacquie
AU - Carrington, Mary
N1 - Funding Information:
Financial support: National Institutes of Health (NIH; grants DA-00441, DA-04334, and DA-13324; HD-43200; contract CO-56000); Bureau of Maternal and Child Health and Resources Development (MCJ-060570), NIH (HD-4-3200), Centers for Disease Control and Prevention, and National Institute of Mental Health (to Hemophilia Growth and DevelopmentStudy); NIH grants to New York Hospital–Cornell Medical Center Clinical Research Center (RR-06020), Mount Sinai General Clinical Research Center, New York (RR-00071), University of Iowa Clinical Research Center (RR-00059), and University of Texas Health Science Center, Houston (RR-02558); National Cancer Institute (contract CP-33002 with Research Triangle Institute to Multicenter Hemophilia Cohort Study).
PY - 2001/7/1
Y1 - 2001/7/1
N2 - A broad, vigorous CD4 T cell response, mediated by class II human leukocyte antigens (HLAs), favors hepatitis C virus (HCV) clearance. HLA-DQB1*0301 has been associated with viral clearance in an ethnically homogeneous cohort. To validate this association and to identify other class II associations in an ethnically varied cohort, molecular class II HLA typing was performed on 200 HCV clearance and 374 matched persistently infected subjects. HLA-DQB1*0301 was weakly associated with viral clearance in combined ethnic groups (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.53-0.97) but was stronger in black subjects. In white subjects, viral clearance was associated with DRB1*0101 (OR, 0.32; 95% CI, 0.17-0.60) and its DQB1*0501 haplotype, whereas viral persistence was associated with DRB1*0301 (OR, 2.36; 95% CI, 1.23-4.52) and its DQB1*0201 haplotype. These results support a role for class II alleles in the immune response to HCV and underscore the importance of studying genetic associations in an ethnically diverse cohort.
AB - A broad, vigorous CD4 T cell response, mediated by class II human leukocyte antigens (HLAs), favors hepatitis C virus (HCV) clearance. HLA-DQB1*0301 has been associated with viral clearance in an ethnically homogeneous cohort. To validate this association and to identify other class II associations in an ethnically varied cohort, molecular class II HLA typing was performed on 200 HCV clearance and 374 matched persistently infected subjects. HLA-DQB1*0301 was weakly associated with viral clearance in combined ethnic groups (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.53-0.97) but was stronger in black subjects. In white subjects, viral clearance was associated with DRB1*0101 (OR, 0.32; 95% CI, 0.17-0.60) and its DQB1*0501 haplotype, whereas viral persistence was associated with DRB1*0301 (OR, 2.36; 95% CI, 1.23-4.52) and its DQB1*0201 haplotype. These results support a role for class II alleles in the immune response to HCV and underscore the importance of studying genetic associations in an ethnically diverse cohort.
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U2 - 10.1086/321005
DO - 10.1086/321005
M3 - Article
C2 - 11398104
AN - SCOPUS:0035399634
SN - 0022-1899
VL - 184
SP - 16
EP - 21
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -