Racemodifies the association between animal protein metabolite1-methylhistidine and blood pressure in middle-aged adults: The BogalusaHeart Study

Alexander C. Razavi, Lydia A. Bazzano, Jiang He, Seamus P. Whelton, Casey M. Rebholz, Camilo Fernandez, Marie Krousel-Wood, Changwei Li, Mengyao Shi, Jovia L. Nierenberg, Shengxu Li, Jason Kinchen, Xuenan Mi, Tanika N. Kelly

Research output: Contribution to journalArticlepeer-review


Dietary factors mediate racial disparities in hypertension. However, the physiological mechanisms underlying this relationship are incompletely understood. We sought to assess the association between 1-methylhistidine (1-MH), a metabolite marker of animal protein consumption, and blood pressure (BP) in a community-based cohort of black and white middle-aged adults. Methods: This analysis consisted of 655 participants of the Bogalusa Heart Study (25% black, 61% women, aged 34-58 years) who were not taking antihypertensive medication. Fasting serum 1-MH was measured using liquid chromatography-tandem mass spectroscopy. Animal food intakes were quantified by food-frequency questionnaires. Multivariable linear regression assessed the association between 1-MH and BP in combined and racestratified analyses, adjusting for demographic, dietary, and cardiometabolic factors. Results: A significant dose-response relationship was observed for the association of red meat (P-trend <0.01) and poultry (P-trend=0.03) intake with serum 1-MH among all individuals. Serum 1-MH, per standard deviation increase, had a significant positive association with SBP (b=3.4±1.6mmHg, P=0.04) and DBP (b=2.0±1.1mmHg, P=0.05) in black participants, whereas no appreciable association was observed in white participants. Among a subgroup of black participants with repeat outcome measures (median follow-up=3.0 years), one standard deviation increase in 1-MH conferred a 3.1 and 2.2mmHg higher annual increase in SBP (P=0.03) and DBP (P=0.03), respectively. Conclusion: Serum 1-MH associates with higher SBP and DBP in blacks, but not whites. These results suggest a utility for further assessing the role of dietary 1-MH among individuals with hypertension to help minimize racial disparities in cardiovascular health.

Original languageEnglish (US)
Pages (from-to)2435-2442
Number of pages8
JournalJournal of hypertension
Issue number12
StatePublished - Dec 2020


  • 1-Methylhistidine
  • African Americans
  • blood pressure
  • diet
  • hypertension
  • metabolomics
  • methylhistidines
  • race factors
  • red meat

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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