Abstract
Morphologically distinct virus like particles (VLP), similar to R type VLP, were observed by electron microscopy in experimental rat central nervous system tumors induced with the B-77-C strain of avian sarcoma virus (ASV). R-type VLP have a characteristic internal radial structure and were observed previously only in hamster cells and in an established bovine cell line. They were not observed in the B-77 ASV inoculum used to induce the rat tumors or in the B-77 induced hamster glioma cells from which the B-77 was rescued. Nevertheless, the genome of an endogenous hamster R-type particle also might have been rescued and carried in the B-77 inoculum. Alternatively, R-type VLP may exist in a number of animal species, including the rat, and may be expressed in certain conditions such as neoplastic transformation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1479-1481 |
| Number of pages | 3 |
| Journal | Journal of the National Cancer Institute |
| Volume | 54 |
| Issue number | 6 |
| State | Published - Dec 1 1975 |
| Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research