TY - JOUR
T1 - Quantitative proton MR spectroscopy as a biomarker of tumor necrosis in the rabbit VX2 liver tumor
AU - Buijs, Manon
AU - Vossen, Josephina A.
AU - Geschwind, Jean-Francois Francois
AU - Salibi, Nouha
AU - Pan, Li
AU - Ventura, Veronica Prieto
AU - Liapi, Eleni A
AU - Lee, Kwang Hun
AU - Kamel, Ihab R.
PY - 2011/8
Y1 - 2011/8
N2 - Purpose: To compare metabolic magnetic resonance (MR) imaging findings (ie, quantification of tumor choline concentration) with percentage of necrosis on pathologic examination in rabbits bearing VX2 liver tumors. Materials and Methods: VX2 tumors were implanted in the livers of 16 rabbits. MR imaging was performed with a 1.5-T MR scanner and extremity coil, and a hydrogen-1 ( 1H) proton MR spectroscopy ( 1H MRS) imaging protocol was used. Rabbits were euthanized immediately after imaging, and the tumor was harvested and sliced at 4-mm intervals in the axial plane. Choline concentration was calculated and was compared with the percentage of tumor necrosis on pathologic examination. Results: Mean tumor size at pathologic examination was 16 mm (range, 1222 mm). Mean percentage of necrosis at pathologic examination was 22% (range, 4%44%). Choline concentration showed a relatively high inverse correlation with percentage of necrosis on pathologic examination, with an r value of 0.78 (P <.002). Conclusions: Choline concentration showed a relatively high inverse correlation with tumor necrosis on pathologic examination. Therefore, 1H MRS may be useful to assess tumor necrosis.
AB - Purpose: To compare metabolic magnetic resonance (MR) imaging findings (ie, quantification of tumor choline concentration) with percentage of necrosis on pathologic examination in rabbits bearing VX2 liver tumors. Materials and Methods: VX2 tumors were implanted in the livers of 16 rabbits. MR imaging was performed with a 1.5-T MR scanner and extremity coil, and a hydrogen-1 ( 1H) proton MR spectroscopy ( 1H MRS) imaging protocol was used. Rabbits were euthanized immediately after imaging, and the tumor was harvested and sliced at 4-mm intervals in the axial plane. Choline concentration was calculated and was compared with the percentage of tumor necrosis on pathologic examination. Results: Mean tumor size at pathologic examination was 16 mm (range, 1222 mm). Mean percentage of necrosis at pathologic examination was 22% (range, 4%44%). Choline concentration showed a relatively high inverse correlation with percentage of necrosis on pathologic examination, with an r value of 0.78 (P <.002). Conclusions: Choline concentration showed a relatively high inverse correlation with tumor necrosis on pathologic examination. Therefore, 1H MRS may be useful to assess tumor necrosis.
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U2 - 10.1016/j.jvir.2011.03.016
DO - 10.1016/j.jvir.2011.03.016
M3 - Article
C2 - 21620723
AN - SCOPUS:80955178993
SN - 1051-0443
VL - 22
SP - 1175
EP - 1180
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 8
ER -