Quantitative proton MR spectroscopy as a biomarker of tumor necrosis in the rabbit VX2 liver tumor

Manon Buijs, Josephina A. Vossen, Jean-Francois Francois Geschwind, Nouha Salibi, Li Pan, Veronica Prieto Ventura, Eleni A Liapi, Kwang Hun Lee, Ihab R. Kamel

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Purpose: To compare metabolic magnetic resonance (MR) imaging findings (ie, quantification of tumor choline concentration) with percentage of necrosis on pathologic examination in rabbits bearing VX2 liver tumors. Materials and Methods: VX2 tumors were implanted in the livers of 16 rabbits. MR imaging was performed with a 1.5-T MR scanner and extremity coil, and a hydrogen-1 ( 1H) proton MR spectroscopy ( 1H MRS) imaging protocol was used. Rabbits were euthanized immediately after imaging, and the tumor was harvested and sliced at 4-mm intervals in the axial plane. Choline concentration was calculated and was compared with the percentage of tumor necrosis on pathologic examination. Results: Mean tumor size at pathologic examination was 16 mm (range, 1222 mm). Mean percentage of necrosis at pathologic examination was 22% (range, 4%44%). Choline concentration showed a relatively high inverse correlation with percentage of necrosis on pathologic examination, with an r value of 0.78 (P <.002). Conclusions: Choline concentration showed a relatively high inverse correlation with tumor necrosis on pathologic examination. Therefore, 1H MRS may be useful to assess tumor necrosis.

Original languageEnglish (US)
Pages (from-to)1175-1180
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Volume22
Issue number8
DOIs
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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