TY - JOUR
T1 - Quantitative proton MR spectroscopic imaging of the human brain
AU - Soher, Brian J.
AU - Van Zijl, Peter C.M.
AU - Duyn, Jeffrey H.
AU - Barker, Peter B.
PY - 1996
Y1 - 1996
N2 - Multislice proton MR spectroscopic images (SI) of the brain were quantitated, using the phantom replacement technique. In 16 normal volunteers, ranging in age from 5 to 74 years, average 'whole brain' concentrations of choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) were found to be 2.4 ± 0.4, 7.9 ± 1.3, and 11.8 ± 1.0 (mM, mean ± SD), respectively. These values are in good general agreement with those previously determined by single-voxel localization techniques. Cortical gray matter was found to have lower Cho and NAA levels, compared to those of white matter, corpus callosum, and basal ganglia. Cho was also found to increase significantly with age in several locations. Quantitative multislice proton SI is feasible in the clinical environment, and regional and age-dependent variations occur that must be accounted for when evaluating spectra from pathological conditions.
AB - Multislice proton MR spectroscopic images (SI) of the brain were quantitated, using the phantom replacement technique. In 16 normal volunteers, ranging in age from 5 to 74 years, average 'whole brain' concentrations of choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) were found to be 2.4 ± 0.4, 7.9 ± 1.3, and 11.8 ± 1.0 (mM, mean ± SD), respectively. These values are in good general agreement with those previously determined by single-voxel localization techniques. Cortical gray matter was found to have lower Cho and NAA levels, compared to those of white matter, corpus callosum, and basal ganglia. Cho was also found to increase significantly with age in several locations. Quantitative multislice proton SI is feasible in the clinical environment, and regional and age-dependent variations occur that must be accounted for when evaluating spectra from pathological conditions.
KW - proton MR spectroscopy
KW - quantitation
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U2 - 10.1002/mrm.1910350313
DO - 10.1002/mrm.1910350313
M3 - Article
C2 - 8699947
AN - SCOPUS:0030050039
SN - 0740-3194
VL - 35
SP - 356
EP - 363
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 3
ER -