Quantitative proton MR spectroscopic imaging in acute disseminated encephalomyelitis

A. Bizzi, A. M. Uluǧ, T. O. Crawford, T. Passe, M. Bugiani, R. N. Bryan, P. B. Barker

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Summary: Serial MR imaging and quantitative proton MR spectroscopic imaging (MRSI) findings of a 4-year-old boy with acute disseminated encephalomyelitis (ADEM) are reported. Over a 2-month period characterized by an initial illness and two relapses, each with full recovery, MR imaging exhibited the appearance and disappearance of multifocal lesions throughout the CNS that correlated only partly with the neurologic impairment. During one relapse, MRSI revealed low levels of N-acetylaspartate (NAA) within the regions of prolonged T2 signal intensity. Ali other metabolites were normal. At follow-up, the MR imaging and MRSI abnormalities had fully resolved. MRSI might play an important role in the diagnosis of ADEM, as well as in the elucidation of underlying pathophysiologic processes in this poorly defined disorder of children. This case demonstrates that reduced levels of NAA are not always associated with neuronal loss, irreversible tissue damage, or poor neurologic outcome.

Original languageEnglish (US)
Pages (from-to)1125-1130
Number of pages6
JournalAmerican Journal of Neuroradiology
Issue number6
StatePublished - Jul 9 2001

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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