Quantitative magnetic resonance imaging analysis of the lacrimal gland in sickle cell disease

Karen Buch, Memi Watanabe, Elliott J. Elias, Joseph H. Liao, Hernan Jara, Rohini N. Nadgir, Naoko Saito, Martin H. Steinberg, Osamu Sakai

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Results: In patients with SCD, significant peak and mean T2 shortening (P < 0.001 and P < 0.001) and increased gland volume (P = 0.008) were observed. Significant correlations were seen between gland volumes in the patients SCD and peak T1 and T2 values (r = 0.6, P = 0.017; r = 0.56; P = 0.031) as well as between gland volumes and mean T1 and T2 values (r = 0.54, P = 0.039; r = 0.57, P = 0.026).

Conclusion: Significant differences in MR relaxometry and lacrimal gland enlargement provide evidence of subclinical lacrimal gland pathology and chronic lacrimal gland changes patients with SCD.

Objectives: Clinical manifestations of sickle cell disease (SCD) can affect the orbit with prior reports describing changes in the lacrimal gland potentially related to chronic vaso-occlusion. The purpose of this study was to evaluate lacrimal gland volumes and quantifiable shifts in MR-relaxation times in patients with SCD.

Methods: Thirteen patients with SCD and 12 age-matched control subjects underwent magnetic resonance imaging (MRI) of the orbits with 1.5-T MRI. Lacrimal glands were segmented manually; and gland volumes, peak, and mean T1- and T2-relaxation times were obtained from histogram analysis.

Original languageEnglish (US)
Pages (from-to)674-680
Number of pages7
JournalJournal of computer assisted tomography
Issue number5
StatePublished - 2014
Externally publishedYes


  • Lacrimal gland
  • Quantitative MRI
  • Relaxometry
  • Sickle cell disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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