TY - JOUR
T1 - Quantitative inhalation bronchial challenge in ragweed hay fever patients
T2 - A comparison with ragweed-allergic asthmatics
AU - Bruce, C. Allen
AU - Rosenthal, Richard R.
AU - Lichtenstein, Lawrence M.
AU - Norman, Philip S.
N1 - Funding Information:
From the Clinical Immunology Division, Department of Medicine, versity School of Medicine at The Good Samaritan Hospital. Supported by Grants Nos. AI 04866, AI 08270, and AI 10304 and Training 00423 from the National Institute of Allergy -. and Infectious Diseases Institutes of Health. Received for publication May 6, 1974. Reprint requests to: Dr. Philip S. Norman, Blvd., Baltimore, Md. 21239. *Research Career Development Diseases, National Institutes
PY - 1975/11
Y1 - 1975/11
N2 - Fourteen ragweed hay fever nonasthmatic patients comparably sensitive to a group of ragweed-allergic asthmatics by skin test and leukocyte histamine release were tested by quantitative inhalation bronchial challenge with ragweed extract. The provocation dose of ragweed extract producing 35% decrease in airway conductance was determined and designated PD35. PD35 values in the hay fever patients were not significantly different from PD35 values in the asthmatic group. These data suggest that carefully performed skin tests may be as diagnostically useful as bronchial challenge in routinely confirming the allergic etiology of seasonal asthma.
AB - Fourteen ragweed hay fever nonasthmatic patients comparably sensitive to a group of ragweed-allergic asthmatics by skin test and leukocyte histamine release were tested by quantitative inhalation bronchial challenge with ragweed extract. The provocation dose of ragweed extract producing 35% decrease in airway conductance was determined and designated PD35. PD35 values in the hay fever patients were not significantly different from PD35 values in the asthmatic group. These data suggest that carefully performed skin tests may be as diagnostically useful as bronchial challenge in routinely confirming the allergic etiology of seasonal asthma.
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U2 - 10.1016/0091-6749(75)90126-8
DO - 10.1016/0091-6749(75)90126-8
M3 - Article
C2 - 52665
AN - SCOPUS:0016826475
SN - 0091-6749
VL - 56
SP - 331
EP - 337
JO - The Journal of allergy and clinical immunology
JF - The Journal of allergy and clinical immunology
IS - 5
ER -