Quantitative effects of typical and atypical neuroleptics on smooth pursuit eye tracking in schizophrenia

Robert E. Litman, Daniel W. Hommer, Allen Radant, Thomas Clem, David Pickar

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Smooth pursuit eye movement (SPEM) gain, total saccades, and subtypes of saccades were quantified from the visual pursuit tracking of 26 fluphenazine-treated patients with schizophrenia and 42 normal controls. Tracking was repeated in 16 patients who underwent a placebo-controlled, double-blind crossover comparison of fluphenazine and clozapine. Fluphenazine-treated patients showed significant reduction in SPEM gain and significant increases in both total, intrusive, and anticipatory saccades and in saccadic amplitude, when compared to controls. Clozapine significantly reduced SPEM gain and significantly increased total and catch-up saccades, when compared to placebo or fluphenazine. High amplitude of intrusive saccades in drug-free patients predicted poor response to clozapine, suggesting that intact frontal cortical function may enable optimal clozapine response.

Original languageEnglish (US)
Pages (from-to)107-120
Number of pages14
JournalSchizophrenia Research
Issue number2
StatePublished - 1994
Externally publishedYes


  • Clozapine
  • Eye tracking
  • Intrusive saccade
  • Typical neuroleptic

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)


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